Two-Step Kinetic Resolution of Racemic Secondary Benzylic Alcohols Using the Combination of Enantioselective Silylation and Acylation: One-Pot Procedure Catalyzed by Chiral Guanidine
Two-Step Kinetic Resolution of Racemic Secondary Benzylic Alcohols Using the Combination of Enantioselective Silylation and Acylation: One-Pot Procedure Catalyzed by Chiral Guanidine
复制标题
使用对映选择性硅烷化和酰化相结合的外消旋仲苯甲醇的两步动力学拆分：手性胍催化的一锅法
DOI：
10.1021/acs.joc.2c01129
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Kenya Nakata
中科院分区：
文献类型：
--
作者：
Kanako Miyazaki;Kenya Nakata
建立了一种新的具有实际对映体比例的外消旋仲苯甲醇的两步动力学拆分方法。这些反应是通过一锅操作进行的，在同一手性胍催化剂的催化下，将对映体选择性硅化和酰化反应结合在一起。
A novel two-step kinetic resolution of racemic secondary benzylic alcohols with practical enantiomeric ratios was achieved. The reactions were carried out via a one-pot operation by combining enantioselective silylation and acylation mediated by the same chiral guanidine catalyst.