Long-term toughness of photopolymerizable (meth)acrylate networks in aqueous environments.
Long-term toughness of photopolymerizable (meth)acrylate networks in aqueous environments.
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DOI：
10.1016/j.actbio.2010.09.001
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发表时间：
2011-02
影响因子：
9.7
通讯作者：
Kathryn E. Smith;P. Trusty;B. Wan;K. Gall
中科院分区：
文献类型：
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作者：
Kathryn E. Smith;P. Trusty;B. Wan;K. Gall
可光聚合的(甲基)丙烯酸酯网络由于其原位形成的能力、快速的合成速率和可定制的材料特性而成为潜在有利的生物材料。本研究的目的是评估磷酸盐缓冲盐水 (PBS) 中的浸泡时间如何影响含有不同浓度 MA 的光聚合丙烯酸甲酯 (MA)-共聚甲基丙烯酸甲酯-共聚(乙二醇)二甲基丙烯酸酯网络的韧性。通过在 PBS 中浸泡不同时间（1 天至 9 个月）后进行拉伸应变至失效测试来确定应力-应变行为。同时，在每个时间点进行差示扫描量热法和 PBS 含量测量，以确定韧性随时间的变化是否与 Tgor PBS 吸收的变化有关。浸泡时间对网络韧性的影响显示出以与聚合物在最初浸泡在 PBS 中时的粘弹性状态相关的方式取决于组成。结果表明，坚韧的丙烯酸酯材料在 PBS 中几个月后可能无法保持其韧性。此外，通过改变网络疏水性来降低 PBS 含量，可以在 9 个月后保持更好的韧性。这些结果提供了一种可能的方法来增韧各种基于无定形丙烯酸酯的植入材料，这些材料正在探索用于承重生物医学应用，超出了本工作中考虑的系统。
Photopolymerizable (meth)acrylate networks are potentially advantageous biomaterials due to their ability to be formed in situ, their fast synthesis rates and their tailorable material properties. The objective of this study was to evaluate how immersion time in phosphate-buffered saline (PBS) affects the toughness of photopolymerizable methyl acrylate (MA)–co-methyl methacrylate–co-poly(ethylene glycol) dimethacrylate networks containing various concentrations of MA. Stress–strain behavior was determined by performing tensile strain to failure testing after soaking in PBS for different periods (1day up to 9months). In tandem, differential scanning calorimetry and PBS content measurements were undertaken at each time point in order to determine whether time-dependent changes in toughness were related to changes in Tgor PBS absorption. The effect of immersion time on network toughness was shown to be dependent upon composition in a manner related to the viscoelastic state of the polymer upon initial immersion in PBS. The results demonstrate that tough acrylate-based materials may not maintain their toughness after several months in PBS. In addition, decreasing the PBS content by changing the network hydrophobicity resulted in better toughness maintenance after 9months. The results provide a possible means to toughen various amorphous acrylate-based implant materials that are being explored for load-bearing biomedical applications, beyond the systems considered in this work.