Factors That Affect Skin Aging A Cohort-Based Survey on Twins
Factors That Affect Skin Aging A Cohort-Based Survey on Twins
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DOI：
10.1001/archdermatol.2009.303
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发表时间：
2009-12-01
影响因子：
--
通讯作者：
Baron, Elma D.
中科院分区：
文献类型：
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作者：
Martires, Kathryn J.;Fu, Pingfu;Baron, Elma D.
Objective: To identify environmental factors that correlate with skin photoaging, controlling for genetic susceptibility by using a questionnaire administered to twins.Design: The survey collected information about each participant's Fitzpatrick type, history of skin cancer, smoking and drinking habits, and weight from a cohort of twins. Clinicians then assigned a clinical photodamage score to each participant.Setting: The annual Twins Days Festival in Twinsburg, Ohio.Participants: A voluntary cohort of twins from the general community, mostly from Ohio, Pennsylvania, and the northeastern United States. The survey was completed on a voluntary basis by sets of monozygotic (MZ) and dizygotic (DZ) twins. A total of 1.30 surveys taken by 65 complete twin pairs were analyzed.Main Outcome Measure: Skin aging was assessed using a validated photographic scale of photodamage, graded by such characteristics as wrinkling and pigmentation change.Results: Photodamage scores among twins of a pair, whether MZ or DZ, were highly correlated (P=.92). Factors found to predict higher photodamage include history of skin cancer (P
