Amniotic membrane transplantation for persistent epithelial defects with ulceration
Amniotic membrane transplantation for persistent epithelial defects with ulceration
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DOI：
10.1016/s0002-9394(14)70125-4
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发表时间：
1997-03-01
影响因子：
4.2
通讯作者：
Tseng, SCG
中科院分区：
文献类型：
--
作者：
Lee, SH;Tseng, SCG
目的：确定保存的人羊膜是否可作为一种替代基质，用于治疗伴有无菌性溃疡的持续性角膜上皮缺损。
方法：对11例因不同原因导致角膜溃疡且平均±标准差持续了17.5±13.9周的连续患者的11只眼进行羊膜移植。
结果：10例患者在3.9±2.3周内愈合（P<0.01），且9.0±5.9个月内无复发。1例因严重类风湿性关节炎导致先前存在角膜穿孔而未能愈合。
结论：在考虑采用结膜瓣或睑裂缝合术治疗之前，对于常规治疗无效的持续性上皮缺损和无菌性溃疡，羊膜移植可被视为一种替代方法。
PURPOSE: To determine whether preserved human amniotic membrane can be used as an alternative substrate for treating persistent corneal epithelial defects with sterile ulceration.METHODS: Amniotic membrane transplantation was performed in 11 eyes of 11 consecutive patients with corneal ulcers of different causes that had persisted for a mean +/- SD of 17.5 +/- 13.9 weeks.RESULTS: Ten patients healed in 3.9 +/- 2.3 weeks (P < .01) without recurrence for 9.0 +/- 5.9 months. One patient failed to heal because of preexisting corneal perforation pursuant to severe rheumatoid arthritis.CONCLUSION: Amniotic membrane transplantation may be considered an alternative method for treating persistent epithelial defects and sterile ulceration that are refractory to conventional treatment and before considering treatment by conjunctival flaps or tarsorrhaphy.