Saliva flow rate, total protein concentration and osmolality as potential markers of whole body hydration status during progressive acute dehydration in humans
Saliva flow rate, total protein concentration and osmolality as potential markers of whole body hydration status during progressive acute dehydration in humans
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DOI：
10.1016/j.archoralbio.2003.08.001
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发表时间：
2004-02-01
影响因子：
3
通讯作者：
Rowlands, AV
中科院分区：
文献类型：
--
作者：
Walsh, NP;Montague, JC;Rowlands, AV
目的：为了确定唾液流速、总蛋白浓度和渗透压是否是全身水合状态的敏感非侵入性标志物，我们比较了进行性急性脱水期间这些参数的变化与体重的变化。设计：12个水分充足的队友报告给实验室后，过夜快速和骑自行车在固定测力计在60%的最大值。在环境室（30 ℃和70%RH）中的氧摄取，直到1.1 +/-0.0、2.0 +/-0.0和2.9 +/-0.2%的进行性体重波动（BML）。运动后，受试者在1小时内摄入相当于150%BML的碳水化合物电解质溶液。在运动前、1.1、2.0和2.9%BML时，然后在运动后75、135和195分钟时，在2分钟内将未刺激的全唾液样品收集到预先称重的管中。结果：在脱水过程中，大蒜总蛋白浓度和渗透压升高，流速降低（P <0.01）。在脱水过程中，大蒜总蛋白浓度和渗透压与%BML密切相关（平均r分别为0.97和0.94：P <0.01）。在脱水过程中，水稻总蛋白浓度与%BML的相关性（P <0.05）大于唾液流率与%BML的相关性（r =-0.88：P <0.01）。结论：这些数据表明，唾液总蛋白浓度和渗透压摩尔浓度的变化，以及在较小程度上流速的变化，与进行性急性脱水期间体重的变化密切相关。(C)2003 Elsevier Ltd. All. rights reserved.
Objective: To identify whether saliva flow rate, total protein concentration and osmolality are sensitive non-invasive markers of whole body hydration status, we compared changes in these parameters with changes in body mass during progressive acute dehydration. Design: Twelve euhydrated mates reported to the laboratory following an overnight fast and cycled on a stationary ergometer at 60% maximal. oxygen uptake in an environmental chamber (30degreesC and 70% RH) until progressive body mass toss (BML) of 1.1 +/- 0.0, 2.0 +/- 0.0 and 2.9 +/- 0.2%. After exercise, subjects were given a volume of carbohydrate electrolyte solution equivalent to 150% BML to consume within 1 h. Unstimulated whole saliva samples were collected over a 2 min period into pre-weighed tubes at pre-exercise, 1.1, 2.0 and 2.9% BML and then at 75, 135 and 195 min post-exercise. Results: Sativa total protein concentration and osmolality increased and flow rate decreased (P < 0.01) during dehydration. Sativa total protein concentration and osmolality correlated strongly with % BML during dehydration (mean r = 0.97 and 0.94, respectively: P < 0.01). The correlation for sativa total protein concentration with % BML was greater (P < 0.05) than the correlation for saliva flow rate with % BML (mean r = -0.88: P < 0.01) during dehydration. Conclusions: These data show that changes in saliva total protein concentration and osmolality, and to a lesser extent flow rate, are strongly associated with changes in body mass during progressive acute dehydration. (C) 2003 Elsevier Ltd. All. rights reserved.