INHIBITION OF SKELETAL-MUSCLE ACTIVITY BY LUNG EXPANSION IN THE DOG
INHIBITION OF SKELETAL-MUSCLE ACTIVITY BY LUNG EXPANSION IN THE DOG
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DOI：
10.1152/jappl.1987.62.5.2058
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发表时间：
1987-05-01
影响因子：
3.3
通讯作者：
CASSIDY, SS
中科院分区：
文献类型：
--
作者：
COAST, JR;THOMPSON, GS;CASSIDY, SS
在麻醉犬中测试肺扩张反射性降低骨骼肌活性的能力。在左肺血管隔离但神经完整的动物中，将左肺静态充气至40 cmH 2 O压力或以10、20或30 ml/kg的潮气量循环充气。将对这些刺激的反应与向左肺动脉注射120或240 μ g辣椒素的反应进行比较。通过左后肢肌肉的肌电图（EMG）反应和对右腿周期性髌腱轻拍（膝跳反射）的单突触反射反应来评估骨骼肌活动。静态充气和10 ml/kg以上的循环充气导致EMG和膝跳反射反应显著降低。结果表明，肺扩张能够引发骨骼肌活动的反射性降低。辣椒素注射引起的反应与肺膨胀引起的反应相似，这表明至少部分骨骼肌对肺膨胀的反射反应可以归因于肺C纤维的刺激，这可能是由肺的拉伸引起的。
The ability of lung expansion to reflexly decrease skeletal muscle activity was tested in anesthetized dogs. In animals whose left lung was vascularly isolated but neurally intact, the left lung was inflated statically to 40 cmH2O pressure or cyclically with tidal volumes of 10, 20, or 30 ml/kg. Responses to these stimuli were compared with those of injecting 120 or 240 .mu.g capsaicin into the left pulmonary artery. Skeletal muscle activity was assessed from the electromyogram (EMG) response of the left hindlimb muscles and from the monosynaptic reflex response to a periodic patellar tendon tap of the right leg (knee jerk). Static inflation and cyclic inflations above 10 ml/kg resulted in significant decreases in both EMG and knee jerk responses. The results indicate that lung expansion is capable of initiating a reflex decrease in skeletal muscle activity. Capsaicin injections caused responses that were similar to those caused by lung inflation, suggesting that at least part of this skeletal muscle reflex response to lung inflation can be attributed to the stimulation of pulmonary C-fibers that could be cuased by stretch of the lung.