New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases.
New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases.
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关于亚精胺在衰老和年龄相关疾病中的作用和机制的新见解
DOI：
10.14336/ad.2021.0603
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发表时间：
2021-12
影响因子：
7.4
通讯作者：
Liu YS
中科院分区：
文献类型：
--
作者：
Ni YQ;Liu YS
老年人群中与年龄相关疾病相关的高发病率和死亡率是一项社会经济挑战。衰老是一个不可逆转且无法避免的过程，是多种年龄相关疾病病理进展的一个风险因素。亚精胺是一种天然多胺，在各种生理和功能过程所涉及的分子与细胞相互作用中发挥着关键作用。研究表明，亚精胺可调节衰老过程、抑制年龄相关疾病的发生并减轻其严重程度，还能延长寿命。然而，亚精胺发挥其抗衰老作用的确切机制尚未明确。在这篇综述中，我们从分子和细胞层面阐释亚精胺对衰老产生有益影响的机制和作用。此外，我们就亚精胺在衰老及年龄相关疾病中具有前景的潜在诊断和治疗应用提供新的见解。
High incidences of morbidity and mortality associated with age-related diseases among the elderly population are a socio-economic challenge. Aging is an irreversible and inevitable process that is a risk factor for pathological progression of diverse age-related diseases. Spermidine, a natural polyamine, plays a critical role in molecular and cellular interactions involved in various physiological and functional processes. Spermidine has been shown to modulate aging, suppress the occurrence and severity of age-related diseases, and prolong lifespan. However, the precise mechanisms through which spermidine exerts its anti-aging effects have not been established. In this review, we elucidate on the mechanisms and roles underlying the beneficial effects of spermidine in aging from a molecular and cellular perspective. Moreover, we provide new insights into the promising potential diagnostic and therapeutic applications of spermidine in aging and age-related diseases.