Age-dependent variation in the serum concentration of mannan-binding protein
Age-dependent variation in the serum concentration of mannan-binding protein
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DOI：
10.1111/j.1651-2227.1996.tb14182.x
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发表时间：
1996-08-01
期刊：
影响因子：
3.8
通讯作者：
Soppi, E
中科院分区：
文献类型：
--
作者：
Aittoniemi, J;Miettinen, A;Soppi, E
甘露聚糖结合蛋白（MBP）是一种急性时相反应物，其缺乏与常见的调理素缺陷、感染易感性和特应性体质有关。本研究的目的是调查发生在婴儿期和儿童后期的血清MBP水平的变化。我们研究了611芬兰不同年龄段的儿童和110名成人的血清MBP浓度，采用酶免疫分析法。对出生当天、1月龄、5月龄、1岁和2岁时连续采集的婴儿血清样本进行分析，发现出生后血清MBP浓度显著升高，1月龄时最高（平均值和中位数分别为8.13和8.49 mg l（-1））。之后，它下降到初始水平，直到5个月大。MBP浓度在儿童期持续下降，12岁后MBP值达到成人水平。在芬兰成年人的平均值和中位数浓度的MBP分别为4.48和4.02毫克升（-1），这似乎是高于以前报道的其他人群。在婴儿中的高浓度的MBP可能是最好的解释暴露于新的环境抗原在幼儿期，这表明一个保护卷：MBP在免疫系统的不成熟期。在年龄较大的儿童中，MBP的高水平可能是由儿童感染和随之而来的MBP需求所解释的。
Mannan-binding protein (MBP) is an acute phase reactant, and its deficiency:is associated with the common opsonic defect and suspectibility to infections and atopic constitution. The aim of this study was to investigate the changes occurring in the serum level of MBP in infancy and during later childhood. We studied the serum concentration of MBP in 611 Finnish children of different ages and 110 adults by using an enzyme immunoassay. In an analysis of successive serum samples from infants at the day of birth and at the ages of 1 and 5 months, and at 1 and 2 years, the serum concentration of MBP increased significantly after birth, and was at its highest (the mean and median were 8.13 and 8.49 mg l(-1), respectively) at the age oi 1 month. After that, it declined to the initial level until the age of 5 months. The MBP concentration continued to decrease during childhood, and after the age of 12 years the MBP values reached the adult level. In Finnish adults the mean and median concentrations of MBP were 4.48 and 4.02 mg l(-1), respectively, which seem to be higher than those reported previously in other populations. The high concentration of MBP in infants may best be explained by exposure to novel environmental antigens in early childhood, which suggests a protective roll: for MBP during the period of immaturity of the immunosystem. In older children the high level of MBP can probably be explained by childhood infections and the ensuing need of MBP.