Diabetes Mellitus and Its Associated Factors in Tuberculosis Patients in Maekel Region, Eritrea: Analytical Cross-Sectional Study.
Diabetes Mellitus and Its Associated Factors in Tuberculosis Patients in Maekel Region, Eritrea: Analytical Cross-Sectional Study.
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DOI：
10.2147/dmso.s293557
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Tuumzghi HA
中科院分区：
文献类型：
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作者：
Araia ZZ;Mesfin AB;Mebrahtu AH;Tewelde AG;Osman R;Tuumzghi HA
糖尿病（DM）和结核病（TB）都是厄立特里亚发病率和死亡率的主要原因。已知结核-糖尿病合并症使结核护理、控制和预防复杂化。然而，我国缺乏系统研究的TB-DM合并症及其相关危险因素的流行病学数据。本研究旨在评估厄立特里亚Maekel地区结核病患者中糖尿病的患病率及其相关因素。在11个结核病诊断和治疗点进行了分析性横断面研究。使用预先测试的数据提取工具从病历中收集数据。使用频率、比例和中位数分析患病率数据。为确定糖尿病的危险因素，采用单变量和多变量logistic回归分析，95% CI和p值< 0.05为显著性。在符合条件的1134例结核病例中，糖尿病患病率为9.88%。年龄和BMI被确定为结核病患者糖尿病的独立危险因素。45 ~ 54岁肺结核患者患糖尿病的几率较高（aOR: 4.85[1.39 ~ 16.94], p= 0.013），≥55岁肺结核患者患糖尿病的几率较高（aOR: 6.99[2.12 ~ 23.04], p= 0.001）。BMI正常的TB患者发生DM的可能性是体重过轻者的2倍（aOR: 2.00[1.23-3.26], p= 0.005）。本研究中观察到的结核病患者中糖尿病的患病率很高，这是一个响亮的呼吁，要求扩大目前的努力，将结核病-糖尿病服务纳入常规护理。此外，年龄和BMI被确定为结核病中糖尿病的独立危险因素，这表明在管理这种合并症时需要注意年龄和BMI状况。
Both diabetes mellitus (DM) and tuberculosis (TB) are among the leading causes of morbidity and mortality in Eritrea. TB-DM comorbidity is known to complicate TB care, control and prevention. However, systematically studied epidemiological data on TB-DM comorbidity and its associated risk factors are lacking in this country. This study aimed to assess the prevalence of DM and its associated factors among TB patients in the Maekel region, Eritrea. Analytical cross-sectional study was conducted in eleven TB diagnostic and treatment sites. Pretested data extraction tool was used to collect data from medical records. Prevalence data were analysed using frequencies, proportions and median. To determine DM risk factors, univariable and multivariable logistic regression analysis was done with 95% CI and p value < 0.05 considered significant. Out of total eligible (1134) TB cases, DM prevalence was 9.88%. Age and BMI were identified as independent risk factors for DM among TB patients. Higher odds of DM were found among TB patients aged 45–54 (aOR: 4.85[1.39–16.94], p= 0.013) and those ≥55 (aOR: 6.99[2.12–23.04], p= 0.001). TB cases with normal BMI were two times more likely to have DM (aOR: 2.00[1.23–3.26], p= 0.005) compared to those underweight. The prevalence of DM among TB cases observed in this study is high, a clarion call to scale up current efforts to integrate TB-DM services within routine care. Furthermore, age and BMI were identified as independent risk factors for DM in TB cases, pointing to the need to pay attention to age and BMI status when managing this co-morbidity.