Capturing ambulatory activity decline in Parkinson's disease.
Capturing ambulatory activity decline in Parkinson's disease.
复制标题
DOI：
10.1097/npt.0b013e318254ba7a
复制
发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Dibble LE
中科院分区：
文献类型：
--
作者：
Cavanaugh JT;Ellis TD;Earhart GM;Ford MP;Foreman KB;Dibble LE
相对而言，人们对与帕金森病（PD）相关的体育活动相关的参与限制的自然演变知之甚少。我们前瞻性地研究了这个问题，使用连续监测技术来捕捉PD患者参与生活情境的自由生活活动。我们特别寻求(1)探索日常活动的自然、长期变化，(2)比较活动参数对步态和疾病严重程度的临床测量的反应性。33名PD患者参与（Hoehn和Yahr范围1-3）。参与者在基线和1年随访期间都佩戴了长达7天的步数活动监测器。平均每日数值计算参数指示的数量，强度，频率，和持续时间的流动活动。临床测量包括统一帕金森病评定量表、6分钟步行和最大步态速度。配对样本的参数检验用于调查动态活动参数和临床测量的变化。参与者在日常活动的数量和强度上有显著下降，但在活动的频率和持续时间上没有显著下降（p < 0.007）。在步态或疾病严重程度的临床测量没有变化的情况下发生下降。最大的1年下降发生在参与者每天花在至少中等强度的移动活动上的分钟数上。连续监测行走活动，而不仅仅是计算步数，可以作为量化与疾病进展相关的行走行为下降或PD患者康复、医疗和/或手术干预导致的行走行为改善的独特而重要的手段。
Relatively little is known about the natural evolution of physical activity-related participation restrictions associated with Parkinson disease (PD). We examined this issue prospectively using continuous monitoring technology to capture the free-living ambulatory activity of persons living with PD engaging in life situations. We specifically sought (1) to explore natural, long-term changes in daily ambulatory activity, and (2) to compare the responsiveness of ambulatory activity parameters to clinical measures of gait and disease severity. Thirty-three persons with PD participated (Hoehn and Yahr range of 1–3). Participants wore a step activity monitor for up to 7 days at baseline and again at 1-year follow-up. Mean daily values were calculated for parameters indicative of amount, intensity, frequency, and duration of ambulatory activity. Clinical measures included the Unified Parkinson Disease Rating Scale, the 6-Minute Walk, and Maximal Gait Speed. Parametric tests for paired samples were used to investigate changes in ambulatory activity parameters and clinical measures. Participants had significant declines in the amount and intensity of daily ambulatory activity but not in its frequency and duration (p < 0.007). Declines occurred in the absence of changes in clinical measures of gait or disease severity. The greatest 1-year decline occurred in the number of daily minutes participants spent engaging in at least moderate-intensity ambulatory activity. Continuous monitoring of ambulatory activity beyond mere step counts may serve as a distinct and important means of quantifying declining ambulatory behavior associated with disease progression or improved ambulatory behavior resulting from rehabilitation, medical, and / or surgical interventions in persons with PD.