Acute exhaustive exercise does not alter lipid peroxidation levels and antioxidant enzyme activities in rat hippocampus, prefrontal cortex and striatum
Acute exhaustive exercise does not alter lipid peroxidation levels and antioxidant enzyme activities in rat hippocampus, prefrontal cortex and striatum
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DOI：
10.1016/j.neulet.2006.07.034
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发表时间：
2006-10-02
影响因子：
2.5
通讯作者：
Kayatekin, Berkant Muammer
中科院分区：
文献类型：
--
作者：
Acikgoz, Osman;Aksu, Ilkay;Kayatekin, Berkant Muammer
虽然经常体育锻炼对身体有益，但众所周知，疲惫的锻炼会导致肌肉中的氧化应激。最近的研究表明，经常进行适度的体育锻炼对大脑有好处。然而，关于精疲力竭的运动是否会在大脑中产生氧化应激的信息很少，而且发现相互矛盾。本研究旨在探讨力竭运动对大鼠海马区、前额叶皮质和纹状体中作为脂质过氧化指标的硫代巴比妥酸反应物质的影响。此外，我们还检测了抗氧化酶、超氧化物歧化酶和谷胱甘肽过氧化物酶的活性，以评估活性氧物种的影响。力竭运动对脑内超氧化物歧化酶、谷胱甘肽过氧化物酶活性和硫代巴比妥酸反应物质水平均无影响，运动后即刻(0min)、运动后3、6、12、24、48h均无明显变化。这些结果表明，急性力竭运动可能不会在运动后引起海马区、前额叶皮质和纹状体明显的脂质过氧化。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
Although regular physical exercise is beneficial to the body, it is well known that exhaustive exercise causes oxidative stress in muscle. Recent studies suggest that regular moderate physical exercise has the beneficial effects on brain. However, there is little information regarding whether or not exhaustive exercise could generate oxidative stress in brain and the findings are conflicting. The aim of this study was to investigate the effects of exhaustive exercise on thiobarbituric acid reactive substances, as an indicator of lipid peroxidation, in the hippocampus, prefrontal cortex and striatum. Additionally we examined antioxidant enzymes activities, superoxide dismutase and glutathione peroxidase, to assess the effects of reactive oxygen species. Exhaustive exercise did not change superoxide dismutase and glutathione peroxidase enzyme activities and thiobarbituric acid reactive substances levels neither immediately (0 min) nor at 3, 6, 12, 24 and 48 h after the cessation of exercise in the brain. These results indicate that acute exhaustive exercise may not cause significant lipid peroxidation in the hippocampus, prefrontal cortex and striatum during the post-exercise period. (c) 2006 Elsevier Ireland Ltd. All rights reserved.