Vasoconstrictor responses in the upper and lower limbs to increases in transmural pressure
Vasoconstrictor responses in the upper and lower limbs to increases in transmural pressure
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DOI：
10.1152/japplphysiol.90449.2008
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发表时间：
2009-01-01
影响因子：
3.3
通讯作者：
Sinoway, Lawrence I.
中科院分区：
文献类型：
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作者：
Lott, Mary E. J.;Hogeman, Cynthia;Sinoway, Lawrence I.
Lott Me，Hogeman C，Herr M，Bhagat M，Kunselman A，Sinoway Li。上肢和下肢对跨壁压力增加的血管收缩反应。应用生理学杂志106：302-310,2009。2008年11月13日首次出版；DOI：10.1152/japplPhysiol.90449.2008。-这项研究的目的是研究人类上肢和下肢血管收缩对跨壁压力变化的反应。测定了20例仰卧位健康受试者(男10例，女10例；27+/-1年；平均+/-SE)在-25、-50、-75、-100 mm Hg4个吸力状态下的平均血流速度(MBV)和血管内径(多普勒超声)。肢体吸引导致MBV最初升高，随后血流速度迅速下降至低于MBV基线的水平，表明血管收缩效应。股动脉较臂血管在所有吸力水平的血流速度下降更大(-89±/-17比-10+/-2，-142+/-11比-14+/-2，-156+/-22比-13+/-2，-162+/-29比-12+/-2毫升/分钟；相互作用效应，P<；0.05)。即使在低吸力水平下(即-10和-20毫米汞柱)，仍显示出较基准值显著的臂部血流速度收缩，反映了下游阻力血管的变化(n=14)。在负槽压改变过程中，臂径和股径没有改变。负压(-25、-50、-75、-25、-50、-75、-25、-50、-75、-25、-50、-75)时，负压吸力时前臂肢体体积变化(1.4+/-0.5%、2.4+/-0.8%、3.5+/-1.0%和4.3+/-1.1%)明显大于小腿(0.9+/-0.5%、1.4+/-0.7%、2.0+/-0.8%和2.8+/-1.1%)。和-100毫米汞柱)。同时测量两个上肢和两个下肢的血流量表明，除了对下肢施加-100毫米汞柱的吸力外，大部分血流量的减少是由于肌源性的影响。与有吸力的手臂相比，腿部更大的血管收缩反应似乎同时受到肌源性和交感神经机制的影响。
Lott ME, Hogeman C, Herr M, Bhagat M, Kunselman A, Sinoway LI. Vasoconstrictor responses in the upper and lower limbs to increases in transmural pressure. J Appl Physiol 106: 302-310, 2009. First published November 13, 2008; doi:10.1152/japplphysiol.90449.2008.-The purpose of this study was to examine upper and lower limb vasoconstrictor responses to changes in transmural pressure in humans. Brachial and femoral blood mean blood velocity (MBV) and vessel diameter (Doppler ultrasound) were measured in 20 supine healthy subjects (10 men and 10 women; 27 +/- 1 yr; mean +/- SE) during four levels of limb suction at -25, -50, -75, and -100 mmHg, respectively. Limb suction led to an initial rise in MBV followed by a rapid fall in flow velocity to a level below MBV baseline, indicating a vasoconstriction effect. Femoral compared with brachial vessels exhibited a greater fall in flow velocity at all levels of suction (-89 +/- 17 vs. -10 +/- 2, -142 +/- 11 vs. -14 +/- 2, -156 +/- 22 vs. -13 +/- 2, and -162 +/- 29 vs. -12 +/- 2 ml/min for -25, -50, -75, and -100 mmHg, respectively; interaction effect, P < 0.05). Even at low tank suction levels (i.e., -10 and -20 mmHg), significant brachial flow velocity vasoconstriction from baseline values was demonstrated, reflecting downstream resistance vessel changes (n = 14). Brachial and femoral diameters did not change during changes in negative tank pressure. During suction, changes in limb volumes were significantly greater in the forearm (1.4 +/- 0.5%, 2.4 +/- 0.8%, 3.5 +/- 1.0%, and 4.3 +/- 1.1%) compared with the calf (0.9 +/- 0.5%, 1.4 +/- 0.7%, 2.0 +/- 0.8%, and 2.8 +/- 1.1%) at all levels of negative tank pressures (-25, -50, -75, and -100 mmHg, respectively). Simultaneous measurements of both upper limbs and both lower limbs suggested that the majority of the reduction in flow was due to myogenic influences except when -100 mmHg of suction was applied to the lower limb. The greater vasoconstriction responses in the leg compared with the arm with suction appear to be influenced by both myogenic and sympathetic mechanisms.