Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units.
Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units.
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DOI：
10.1136/bjophthalmol-2017-311789
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
TR-ROP Study Group
中科院分区：
文献类型：
--
作者：
Bas AY;Demirel N;Koc E;Ulubas Isik D;Hirfanoglu İM;Tunc T;TR-ROP Study Group
评估土耳其早产儿视网膜病变（ROP）的患病率、危险因素和治疗，并建立该疾病的筛查标准。在2016年4月1日至2017年4月30日期间，在69个新生儿重症监护室（NICU）中进行了一项前瞻性队列研究（TR-ROP）。研究纳入了出生体重（BW）≤1500 g或胎龄（GA）≤32周的婴儿以及BW>1500 g或GA>32周且临床病程不稳定的婴儿。通过logistic回归分析确定ROP发展的预测因素。TR-ROP研究包括6115名婴儿：4964名（81%）GA≤32周，1151名（19%）GA>32周。总的来说，27%的人有任何阶段的ROP，6.7%的人有严重的ROP。BW≤1500 g的婴儿中，较低的BW、较小的GA、吸氧总天数、迟发性脓毒症、红细胞输注频率和相对体重增加被确定为严重ROP的独立风险因素。在所有婴儿中，414例需要治疗，395例（95.4%）接受治疗的婴儿BW≤1500 g。66例（16%）接受治疗的婴儿不符合早产儿视网膜病早期治疗的治疗要求。在土耳其，筛查GA≤34周或BW<1700 g的婴儿似乎是合适的。建议在全国范围内监测新生儿护理标准并开展质量改进项目，以改善土耳其NICU的新生儿结局。 NCT 02814929，结果。
To evaluate the prevalence, risk factors and treatment of retinopathy of prematurity (ROP) in Turkey and to establish screening criteria for this condition. A prospective cohort study (TR-ROP) was performed between 1 April 2016 and 30 April 2017 in 69 neonatal intensive care units (NICUs). Infants with a birth weight (BW)≤1500 g or gestational age (GA)≤32 weeks and those with a BW>1500 g or GA>32 weeks with an unstable clinical course were included in the study. Predictors for the development of ROP were determined by logistic regression analyses. The TR-ROP study included 6115 infants: 4964 (81%) with a GA≤32 weeks and 1151 (19%) with a GA>32 weeks. Overall, 27% had any stage of ROP and 6.7% had severe ROP. A lower BW, smaller GA, total days on oxygen, late-onset sepsis, frequency of red blood cell transfusions and relative weight gain were identified as independent risk factors for severe ROP in infants with a BW≤1500 g. Of all infants, 414 needed treatment and 395 (95.4%) of the treated infants had a BW≤1500 g. Sixty-six (16%) of the treated infants did not fulfil the Early Treatment for Retinopathy of Prematurity requirements for treatment. Screening of infants with a GA≤34 weeks or a BW<1700 g appears to be appropriate in Turkey. Monitoring standards of neonatal care and conducting quality improvement projects across the country are recommended to improve neonatal outcomes in Turkish NICUs. NCT02814929, Results.
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