HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF CHLORHEXIDINE PHOSPHANILATE, A NEW ANTIMICROBIAL AGENT
HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF CHLORHEXIDINE PHOSPHANILATE, A NEW ANTIMICROBIAL AGENT
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DOI：
10.1016/0731-7085(91)80040-g
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发表时间：
1991-01-01
影响因子：
3.4
通讯作者：
PEER, MM
中科院分区：
文献类型：
--
作者：
GADDE, RR;MCNIFF, EF;PEER, MM
Chlorhexidine phosphanilate (CHP) is analysed by two separate reversed-phase HPLC methods. CHP was found to be a non-stoichiometric compound with a phosphanilic acid to chlorhexidine ratio of 1.83. By careful choice of solvents, solution pH and HPLC columns, loss of sample due to incomplete dissolution and adsorption to surfaces is avoided. Both methods are shown to be stability-indicating and accurate.
