Long-Lived Ames Dwarf Mice Are Resistant to Chemical Stressors
Long-Lived Ames Dwarf Mice Are Resistant to Chemical Stressors
复制标题
DOI：
10.1093/gerona/glp052
复制
发表时间：
2009-08-01
影响因子：
5.1
通讯作者：
Richardson, Arlan
中科院分区：
文献类型：
--
作者：
Bokov, Alex F.;Lindsey, Merry L.;Richardson, Arlan
为了探讨长寿与抗压能力之间的关系，我们比较了 Ames 长寿侏儒小鼠和对照同窝小鼠对百草枯、敌草快和多巴酚丁胺的敏感性。在年轻成年动物中，服用百草枯后，95% 的雄性和 39% 的雌性对照死亡，但没有侏儒动物死亡。当在较大年龄或较高剂量的百草枯重复实验时，侏儒小鼠仍然表现出更大的抵抗力。侏儒小鼠对敌草快的抵抗力也更强。尽管侏儒小鼠的肝脏对敌草快更加敏感，但雄性对照小鼠的死亡率为 80%，雌性对照小鼠的死亡率为 60%，而侏儒小鼠的死亡率为 40% 和 20%。侏儒小鼠对多巴酚丁胺诱导的心脏应激也不太敏感，并且肝脏和肺中的 F-2-异前列腺素水平较低。这是第一个直接的体内证据，表明长寿的艾姆斯侏儒小鼠对化学损伤，特别是氧化应激源的抵抗力增强。
To probe the connection between longevity and stress resistance, we compared the sensitivity of Ames long-lived dwarf mice and control littermates with paraquat, diquat, and dobutamine. In young adult animals, 95% of male and 39% of female controls died after paraquat administration, but no dwarf animals died. When the experiment was repeated at an older age or a higher dosage of paraquat, dwarf mice still showed greater resistance. Dwarf mice also were more resistant to diquat; 80% of male and 60% of female controls died compared with 40% and 20% of dwarf mice, despite greater sensitivity of dwarf liver to diquat. Dwarf mice were also less sensitive to dobutamine-induced cardiac stress and had lower levels of liver and lung F-2-isoprostanes. This is the first direct in vivo evidence that long-lived Ames dwarf mice have enhanced resistance to chemical insult, particularly oxidative stressors.