Ethiodized oil emulsions in hepatic microcirculation: In vivo microscopy in animal models
Ethiodized oil emulsions in hepatic microcirculation: In vivo microscopy in animal models
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DOI：
10.1016/s1076-6332(97)80029-3
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发表时间：
1997-04-01
影响因子：
4.8
通讯作者：
Wallace, S
中科院分区：
文献类型：
--
作者：
Kan, ZX;Wright, K;Wallace, S
理论基础和目标。作者的目的是确定乙基碘化油乳剂在肝脏循环中的稳定性和载药和释药能力。将含有阿霉素的非离子造影剂与乙基碘化油按不同比例制成的乳剂注入正常和荷瘤大鼠肝脏的肝动脉。采用体内显微镜观察乳剂在肝循环中的动态分布。较少的水与较多的油混合形成油包水(W/O)相乳状液，而较少的油与较多的水混合形成水包油(O/W)乳状液。乳状液中的油携带血液循环中的水。W/O乳剂的载药量和释药时间均显著高于O/W乳剂(P<；.01)。W/O乳状液的输送能力优于O/W乳状液。有关乳剂的制备方法和肝脏给药能力的进一步研究是有必要的。
Rationale and Objectives. The authors' purpose was to define the stability and drug-carrying and drug-releasing capacity of ethiodized oil emulsions in the hepatic circulation.Methods. Emulsions prepared in various ratios of a nonionic contrast material containing doxorubicin to ethiodized oil were injected into the hepatic arteries of normal and tumor-bearing livers in rats or mice. In vivo microscopy was used to observe the dynamic distribution of the emulsions in the hepatic circulation.Results. A solution of less water mixed with more oil formed water-in-oil (w/o) phase emulsions, whereas less oil with more water formed oil-in-water (o/w) emulsions. The oil in the emulsions carried the water in the blood circulation. The w/o emulsions exhibited significantly higher carriage capacity and longer release time for the drug solution than did the o/w emulsions (P < .01).Conclusion. The delivery capacity of w/o emulsions is superior to that of o/w emulsions. Further studies about preparation methods and delivery capability of emulsions in the liver are warranted.