Nicotine delivery and users' reactions to Juul compared with cigarettes and other e-cigarette products
Nicotine delivery and users' reactions to Juul compared with cigarettes and other e-cigarette products
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DOI：
10.1111/add.14936
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发表时间：
2020-06-01
期刊：
影响因子：
6
通讯作者：
Przulj, Dunja
中科院分区：
文献类型：
--
作者：
Hajek, Peter;Pittaccio, Kate;Przulj, Dunja
目的评估药代动力学（PK）的配置文件，和用户的反应，Juul（59毫克尼古丁/毫升）作为其治疗和依赖potential.Design的指示，交叉，在受试者内的研究，参与者参加后，过夜禁欲单独的会议和吸烟或使用Juul或其他八种类型的电子烟（EC）随意5分钟。所使用的Juul产品是在美国可用的版本，其电子液体中的尼古丁含量高于欧盟可用的版本。设置英国的实验室设置。（吸烟者也使用电子烟）提供了Juul和香烟的数据，其中8人还提供了其他EC产品的数据。在5分钟的产品使用期间对抽吸的次数进行计数，并在基线和开始吸烟/吸电子烟后2、4、6、8、10和30分钟采集血液样品，并分析尼古丁。参与者还监测他们的冲动吸烟和评级的产品上的一系列characteristic.Findings Juul的PK曲线接近的PK曲线的香烟[最大浓度（C-最大值）= 20. 4与19. 2 ng/ml;时间达到最大浓度（T-最大值）= 4与6分钟;曲线下面积（AUC）：307. 9与312. 6，分别]。与其他EC产品相比，Juul的Tmax较短[4分钟，（IQR = 2.5-4.0）对比6.3分钟，（IQR = 4.7 - 8.1），P = 0.012]和更高的C-max（28.9（SD = 15.6）vs 10.6（SD = 5.5），P = 0.013），尽管抽吸次数较少（12.5（SD = 4.2）vs 17.0（SD = 4.2），P = 0.084）。与其他电子烟产品相比，它也提供了更快的减少吸烟的冲动，并获得了更有利的主观ratings.Conclusion Juul的PK特征和用户评级表明，它可能比其他EC产品更有效地帮助吸烟者戒烟，但它也可能有一个更高的潜力，产生经常使用的非吸烟者。
Aims To assess the pharmacokinetic (PK) profile of, and users' reactions to, Juul (59 mg nicotine/ml) as an indication of its therapeutic and dependence potential.Design Cross-over, within-subjects study in which participants attended after overnight abstinence on separate sessions and smoked a cigarette or used Juul or eight other types of e-cigarettes (EC) ad libitum for 5 minutes. The Juul product used was the version available in the United States that has more nicotine in the e-liquid than the one available in the European Union.Setting Laboratory setting in the United Kingdom.Participants Twenty dual users (smokers who also vape) provided data on Juul and cigarettes, with eight also providing data on other EC products.Measurements At each session, number of puffs taken was counted during the 5-minute product use period and blood samples were taken at baseline and at 2, 4, 6, 8, 10 and 30 minutes after starting smoking/vaping and analysed for nicotine. Participants also monitored their urges to smoke and rated the products on a range of characteristics.Findings Juul's PK profile was close to the PK profile of cigarettes [maximum concentration (C-max) = 20.4 versus 19.2 ng/ml; time to maximum concentration (T-max) = 4 versus 6 minutes; area under the curve (AUC): 307.9 versus 312.6, respectively]. Compared with other EC products, Juul had shorter T-max [4 minutes, (IQR = 2.5-4.0) versus 6.3 minutes, (IQR = 4.7 - 8.1), P = 0.012] and higher C-max (28.9 (SD = 15.6) versus 10.6 (SD = 5.5), P = 0.013) despite a lower number of puffs (12.5 (SD = 4.2) versus 17.0 (SD = 4.2), P = 0.084). Compared with other e-cigarette products, it also provided faster reduction of urges to smoke and obtained more favourable subjective ratings.Conclusion Juul's PK profile and user ratings suggest that it could be more effective than other EC products in helping smokers to quit smoking, but it may also have a higher potential to generate regular use in non-smokers.