Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention.
Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention.
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DOI：
10.1007/s40495-014-0002-x
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发表时间：
2015-04-01
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萝卜硫素（SFN）是一种来源于十字花科蔬菜的植物化学物质，具有多种分子靶点和抗癌特性。研究人员已经证明了SFN消耗的几种化学预防益处，例如减少肿瘤生长，增加癌细胞凋亡，以及在体外和体内破坏肿瘤微环境中的信号传导。新出现的证据表明，SFN通过改变表观遗传机制发挥其化学预防作用。这篇综述总结了SFN对表观遗传事件的影响的证据，以及它们如何与在乳腺癌和前列腺癌的临床前和临床研究中观察到的SFN的化学预防作用有关。关注的具体领域包括SFN在细胞周期，细胞凋亡，炎症，抗氧化防御和癌细胞信号转导调节中的作用及其与表观遗传机制的关系。最后，剩余的挑战和研究需要与SFN转换成人体研究和临床干预试验的机械工作进行了讨论。
Sulforaphane (SFN) is a phytochemical derived from cruciferous vegetables that has multiple molecular targets and anti-cancer properties. Researchers have demonstrated several chemopreventive benefits of SFN consumption, such as reductions in tumor growth, increases in cancer cell apoptosis, and disruption of signaling within tumor microenvironments both in vitro and in vivo. Emerging evidence indicates that SFN exerts several of its chemopreventive effects by altering epigenetic mechanisms. This review summarizes evidence of the impact of SFN on epigenetic events and how they relate to the chemopreventive effects of SFN observed in preclinical and clinical studies of breast and prostate cancers. Specific areas of focus include the role of SFN in the regulation of cell cycle, apoptosis, inflammation, antioxidant defense, and cancer cell signaling and their relationships to epigenetic mechanisms. Finally, remaining challenges and research needs for translating mechanistic work with SFN into human studies and clinical intervention trials are discussed.