[Gastric adenocarcinoma of the fundic gland type: clinicopathological analysis of six cases].
[Gastric adenocarcinoma of the fundic gland type: clinicopathological analysis of six cases].
复制标题
DOI：
10.3760/cma.j.cn112151-20190720-00404
复制
发表时间：
2020-04-08
期刊：
影响因子：
--
通讯作者：
Da, Q
中科院分区：
文献类型：
--
作者：
Sun, W W;Zhang, L;Da, Q
目的：探讨胃底腺腺癌（GA-FG）的临床病理特点。研究方法：2014年1月至2019年5月，上海市松江区中心医院共收治6例GA-FG患者，分析其内镜表现、病理特征和免疫组化染色，并复习相关文献。结果：6例患者中，男性3例，女性3例，平均年龄66岁。最常见的临床表现是上腹部不适。胃镜检查发现胃体部有一个直径为0.4 - 1.0 cm的隆起或扁平病变。组织病理学上，主要由主细胞组成，但也有散在的壁细胞，排列成不规则的管状或索状结构，并形成吻合支。肿瘤细胞对MUC 6和胃蛋白酶原1呈免疫化学阳性。结论：GA-FG是高分化腺癌的一种罕见变异。了解其临床特征和组织形态学对提高诊断率有重要意义。
Objective: To investigate the clinicopathological characteristics of gastric adenocarcinoma of the fundic gland(GA-FG). Methods: A total of 6 patients with GA-FG admitted from January 2014 to May 2019 were identified at Shanghai Songjiang District Central Hospital.Analyzed endoscopic findings, pathological characteristics and immunohistochemical staining of the lesions and reviewed relevant literatures. Results: Among the 6 patients, 3 were male, 3 were female, and the mean age was 66 years. The most common clinical presentation was epigastric discomfort. Gastroscopic examination revealed an elevated or flat lesion in the body of the stomach, with a diameter of 0.4 to 1.0 cm. Histopathologically, they mainly composed of main cells, but there were also scattered parietal cells, arranged in an irregular tubular or cord-like structure, and formed anastomosis branches. The tumor cells were immunohistochemically positive for MUC6 and pepsinogen 1. Conclusions: GA-FG is a rare variant of well-differentiated adenocarcinoma. It is important to understand its clinical features and histological morphology for more accurate diagnosis.