Segmentational Analysis of Retinal Thickness after Vitrectomy in Diabetic Macular Edema
Segmentational Analysis of Retinal Thickness after Vitrectomy in Diabetic Macular Edema
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DOI：
10.1167/iovs.12-9934
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发表时间：
2012-09-01
影响因子：
4.4
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
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作者：
Murakami, Tomoaki;Nishijima, Kazuaki;Yoshimura, Nagahisa
目的.应用光谱域光学相干断层扫描（SD-OCT）测量糖尿病黄斑水肿（DME）玻璃体切除术后视网膜内外厚度，并评价其与logMAR的关系。在该回顾性病例系列中，连续有55只患有DME的眼睛接受了玻璃体切除术。人工测量视网膜旁亚视野的总视网膜厚度、内部厚度（从视网膜最内层到内核层）和外部厚度（从外网层到视网膜色素上皮），并评价与logMAR的相关性。中央、鼻侧和下亚视野的总视网膜厚度与基线logMAR显著相关（分别为r = 0.37，P = 0.005; r = 0.29，P = 0.032; r = 0.33，P = 0.015）;末次访视时，无亚视野厚度与logMAR相关。然而，分段分析显示，颞叶视网膜外区厚度与中央凹内外节段之间连接的破坏有关（P = 0.021和P = 0.005），与6个月和末次访视时的logMAR呈负相关（r =-0.37，P = 0.006和r =-0.28，P = 0.042）。玻璃体切除术后，鼻侧亚区的内部厚度与其他亚区和鼻旁区所有亚区的外部厚度相比没有变化;基线鼻总厚度与6个月和末次访视时的logMAR相关性最显著（r = 0.40，P = 0.002和r = 0.37，P = 0.006）。节段性分析为考虑DME玻璃体切除术后的预后和发病机制提供了有用的信息。（Invest Ophthalmol维斯科学。2012;53：6668-6674）DOI：10.1167/iovs.12-9934
PURPOSE. To measure the inner and outer retinal thicknesses on spectral-domain optical coherence tomography (SD-OCT) and evaluate their association with logMAR after vitrectomy for diabetic macular edema (DME).METHODS. In this retrospective case series, there were 55 consecutive eyes with DME for which vitrectomy was performed. The total retinal thickness, the inner thickness (from the innermost of the retina to the inner nuclear layer), and the outer thickness (from the outer plexiform layer to the retinal pigment epithelium) in the parafoveal subfields were measured manually, and the association with logMAR was evaluated.RESULTS. The total retinal thicknesses in the central, nasal, and inferior subfields were significantly (r = 0.37, P = 0.005; r = 0.29, P = 0.032; r = 0.33, P = 0.015, respectively) associated with the baseline logMAR; no subfield thickness was correlated with the logMAR at the final visit. However, segmentational analysis showed that the outer retinal thickness of the temporal subfield was associated with disruption of the junction between the inner and outer segments at the fovea (P = 0.021 and P = 0.005) and negatively correlated with the logMAR (r = -0.37, P = 0.006 and r = -0.28, P = 0.042) at the 6-month and final visit. The inner thickness of the nasal subfield did not change after vitrectomy compared with the other subfields and the outer thickness of all subfields in the parafoveal area; the baseline nasal total thickness was correlated most significantly with the logMAR (r = 0.40, P = 0.002 and r = 0.37, P = 0.006) at the 6-month and final visits.CONCLUSIONS. Segmentational analysis provided useful information for considering the prognosis and pathogenesis after vitrectomy for DME. (Invest Ophthalmol Vis Sci. 2012;53:6668-6674) DOI:10.1167/iovs.12-9934