The Effects of Malaria in Pregnancy on Neurocognitive Development in Children at 1 and 6 Years of Age in Benin: A Prospective Mother-Child Cohort.
The Effects of Malaria in Pregnancy on Neurocognitive Development in Children at 1 and 6 Years of Age in Benin: A Prospective Mother-Child Cohort.
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DOI：
10.1093/cid/ciab569
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发表时间：
2022-03-09
期刊：
影响因子：
--
通讯作者：
Bodeau-Livinec F
中科院分区：
文献类型：
--
作者：
Garrison A;Boivin MJ;Fiévet N;Zoumenou R;Alao JM;Massougbodji A;Cot M;Bodeau-Livinec F
妊娠期疟疾对撒哈拉以南非洲的婴儿死亡率有很大影响，并对幸存者造成早产和低出生体重等后果。然而，它对儿童长期神经认知发展的影响仍不清楚。我们的前瞻性队列包括妊娠预防替代药物临床试验中的孕妇及其活体出生的独生子女。用显微镜和实时定量聚合酶链式反应(QPCR)检测MIP。分别在1岁和6岁时使用马伦早期学习量表和考夫曼儿童成套测验第二版(KABC-II)评估儿童的神经认知发展。在493名孕妇中，196名(40%)至少感染过一次疟疾：121名(31%)经qPCR诊断为胎盘性疟疾。多因素线性回归B系数显示，粗大运动评分受损与胎盘疟疾(−2.5 5；95%CI：−5.15，0.0 5)、胎盘疟疾(−4.95；95%CI：−7.6 5，−2.2 4)、产后高寄生虫密度(−1.92；95%CI：−3.86，0.0 2)至少有1次关联。疟疾和第二次产前检查的高寄生虫密度与6年后KABC-II非语言指数得分较低(−2.57[95%CI：−4.86，−0.28]和−1.91[−3.51，−0.32])相关。这项前瞻性队列研究提供的证据表明，MiP，特别是晚期，可能会对1岁和6岁的儿童发展产生重要的负面影响。必须进一步调查这种关联背后的机制，并应加强低收入国家的诊断方法，以提供适当的治疗。NCT00811421。在非洲撒哈拉以南的贝宁，这篇论文首次提供了妊娠晚期外周和胎盘疟疾与1岁和6岁儿童神经认知发育受损之间的关联的第一个证据。
Malaria in pregnancy (MiP) contributes significantly to infant mortality rates in sub-Saharan Africa and has consequences on survivors, such as preterm birth and low birth weight. However, its impact on long-term neurocognitive development in children remains unknown. Our prospective cohort included pregnant women and their live-born singletons from the Malaria in Pregnancy Preventive Alternative Drugs clinical trial. MiP was assessed using microscopy and real-time quantitative polymerase chain reaction (qPCR). Neurocognitive development in children was assessed using the Mullen Scales of Early Learning and the Kaufman Assessment Battery for Children, 2nd edition (KABC-II), at 1 and 6 years of age, respectively. Of 493 pregnant women, 196 (40%) were infected with malaria at least once: 121 (31%) with placental malaria diagnosed by qPCR. Multiple linear regression B-coefficients showed that impaired gross motor scores were associated with MiP at least once (−2.55; confidence interval [95% CI]: −5.15, 0.05), placental malaria by qPCR (−4.95; 95% CI: −7.65, −2.24), and high parasite density at delivery (−1.92; 95% CI: −3.86, 0.02) after adjustment. Malaria and high parasite density at the second antenatal care visit were associated with lower KABC-II Non-Verbal Index scores at 6 years (−2.57 [95% CI: −4.86, −0.28] and −1.91 [−3.51, −0.32]), respectively. This prospective cohort study provides evidence that MiP, particularly late term, could have important negative consequences on child development at 1 and 6 years of age. Mechanisms behind this association must be further investigated and diagnostic methods in low-income countries should be strengthened to provide adequate treatment. NCT00811421. This paper provides the first evidence of an association between late-term peripheral and placental malaria in pregnancy and impaired neurocognitive development in offspring at 1 and 6 years of age in Benin, sub-Saharan Africa.
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影响因子：
3.7
作者：
Kalilani-Phiri, Linda;Thesing, Phillip C.;Laufer, Miriam K.
通讯作者：
Laufer, Miriam K.
DOI：
10.1080/09297049.2021.1876012
发表时间：
2021-05
期刊：
Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence
影响因子：
--
作者：
Boivin MJ;Zoumenou R;Sikorskii A;Fievet N;Alao J;Davidson L;Cot M;Massougbodji A;Bodeau-Livinec F
通讯作者：
Bodeau-Livinec F
DOI：
10.1097/dbp.0b013e31829d211c
发表时间：
2013-09-01
影响因子：
2.4
作者：
Koura, Kobto G.;Boivin, Michael J.;Bodeau-Livinec, Florence
通讯作者：
Bodeau-Livinec, Florence
影响因子：
2.9
作者：
Le Port A;Cottrell G;Martin-Prevel Y;Migot-Nabias F;Cot M;Garcia A
通讯作者：
Garcia A
影响因子：
15.8
作者：
Elphinstone, Robyn E.;Weckman, Andrea M.;Kain, Kevin C.
通讯作者：
Kain, Kevin C.