Mitosin, a novel marker of cell proliferation and early recurrence in intracranial meningiomas
Mitosin, a novel marker of cell proliferation and early recurrence in intracranial meningiomas
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DOI：
10.14670/hh-18.67
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发表时间：
2003-01-01
影响因子：
2
通讯作者：
Davaris, P
中科院分区：
文献类型：
--
作者：
Konstantinidou, AE;Korkolopoulou, P;Davaris, P
在连续的47例原发性颅内良性和非典型脑膜瘤患者中，免疫组织化学评估了丝裂蛋白（一种新的增殖相关分子）的表达。丝裂蛋白的表达与增殖标志物Ki-67 （MIB-1）、增殖细胞核抗原（PCNA）、拓扑异构酶i- α (topoiiα)和有丝分裂指数相关，并与标准临床病理参数和患者预后相关。7例肿瘤在全切除后复发（14.8%），随访时间为21至108个月（中位60个月）。有丝分裂蛋白和PCNA的增殖指标较高，Topolla的增殖指标较低。丝分裂酶标记指数（LI）范围从0.1到57%（中位数为3%），不同等级之间的值有显著的重叠。有丝分裂蛋白LI与Ki-67 LI呈显著正相关(p
The expression of mitosin, a novelproliferation-associated molecule was evaluated immunohistochemically in a consecutive series of 47 patients with primary intracranial benign and atypical meningiomas. Mitosin expression was correlated with proliferation markers Ki-67 (MIB-1), proliferating cell nuclear antigen (PCNA), topoisomerase IIalpha (TopoIIalpha) and mitotic index, as well as with standard clinicopathological parameters and patient outcome. Seven tumors recurred (14.8%) following gross total resection, within a follow-up period ranging from 21 to 108 months (median 60 months). The higher proliferation indices were obtained with mitosin and PCNA and the lower ones with Topolla. Mitosin labeling index (LI) ranged from 0.1 to 57% (median 3%), with a significant overlapping of values between grades. A significant positive correlation was shown between mitosin LI on the one hand and Ki-67 LI (p