Revisiting Seed and Soil: Examining the Primary Tumor and Cancer Cell Foraging in Metastasis.
Revisiting Seed and Soil: Examining the Primary Tumor and Cancer Cell Foraging in Metastasis.
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DOI：
10.1158/1541-7786.mcr-16-0436
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Amend SR
中科院分区：
文献类型：
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作者：
de Groot AE;Roy S;Brown JS;Pienta KJ;Amend SR
转移是癌细胞从原发肿瘤扩散，遍及全身，并侵袭和定居在远处的结果。基于Paget的1889年假说，大多数现代转移研究集中在转移的“种子和土壤”的性质上，而原发肿瘤的“土壤”的含义在很大程度上被忽视了。由于原发肿瘤的选择性压力，出现了罕见的致命性转移“种子”。最优觅食理论描述了癌细胞如何采用移动觅食策略来平衡捕食风险和资源回报。在原发肿瘤外的扩散通道中的进一步选择增强了潜在转移细胞的适应性。这篇综述主要关注产生致命转移“种子”的原发肿瘤“土壤”的选择压力，这对于理解前列腺癌转移的关键成分是必不可少的。阐明产生致命转移“种子”的原发肿瘤“土壤”的选择压力对于理解前列腺癌转移是如何发生以及为什么发生的至关重要。
Metastasis is the consequence of a cancer cell that disperses from the primary tumor, travels throughout the body, and invades and colonizes a distant site. Based on Paget’s 1889 hypothesis, the majority of modern metastasis research focuses on the properties of the metastatic “seed and soil,” but the implications of the primary tumor “soil” have been largely neglected. The rare lethal metastatic “seed” arises as a result of the selective pressures in the primary tumor. Optimal foraging theory describes how cancer cells adopt a mobile foraging strategy to balance predation risk and resource reward. Further selection in the dispersal corridors leading out of the primary tumor enhances the adaptive profile of the potentially metastatic cell. This review focuses on the selective pressures of the primary tumor “soil” that generate lethal metastatic “seeds” which is essential to understanding this critical component of prostate cancer metastasis. Elucidating the selective pressures of the primary tumor “soil” that generate lethal metastatic “seeds” is essential to understand how and why metastasis occurs in prostate cancer.