High expression of adenylate cyclase-associated protein 1 accelerates the proliferation, migration and invasion of neural glioma cells
High expression of adenylate cyclase-associated protein 1 accelerates the proliferation, migration and invasion of neural glioma cells
复制标题
腺苷酸环化酶相关蛋白1的高表达加速神经胶质瘤细胞的增殖、迁移和侵袭
DOI：
10.1016/j.prp.2015.12.017
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发表时间：
2016-01-01
影响因子：
2.8
通讯作者：
Cui, Gang
中科院分区：
文献类型：
--
作者：
Bao, Zhen;Qiu, Xiaojun;Cui, Gang
Adenylate cyclase-associated protein 1 (CAP1), a conserved member of cyclase-associated proteins was reported to be associated with the proliferation, migration or invasion of the tumors of pancreas, breast and liver, and was involved in astrocyte proliferation after acute Traumatic Brain Injury (TBI). In this study, we sought to investigate the character of CAP1 in the pathological process of human glioma by detecting human glioma specimens and cell lines. 43 of 100 specimens showed high expression of CAP1 via immunohistochemistry. With statistics analysis, we found out the expression level of CAP1 was correlated with the WHO grades of human glioma and was great positively related to Ki-67 (p < 0.01). In vitro, silencing CAP1 in U251 and U87MG, the glioma cell lines with the relatively higher expression of CAP1, induced the proliferation of the cells significantly retarded, migration and invasion as well. Obviously, our results indicated that CAP1 participated in the molecular pathological process of giloma indeed, and in a certain sense, CAP1 might be a potential and promising molecular target for glioma diagnosis and therapies in the future. (C) 2016 Elsevier GmbH. All rights reserved.
