The relationship of conjoint traits of dyslipidemias between young offspring and their parents in a community-based sample.
The relationship of conjoint traits of dyslipidemias between young offspring and their parents in a community-based sample.
复制标题
基于社区的样本中年轻后代与其父母之间血脂异常联合特征的关系。
DOI：
10.1006/pmed.1997.0197
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Berenson,GS
中科院分区：
文献类型：
--
作者：
Chen,W;Srinivasan,SR;Bao,W;Wattigney,WA;Berenson,GS
BackgroundThe关系dyslipidiasbetween年轻的后代和他们的父母进行了检查，以评估其有用性在预测血脂紊乱的父母和children.MethodsYoung的后代年龄5-17岁，他们的父母进行了研究，在一个以社区为基础的样本477个家庭。结果父母血脂异常类型相同的儿童发生同一种血脂异常的频率最高（P <0.001 ~ P <0.05），父母血脂异常类型相同的儿童发生同一种血脂异常的频率最高（P< 0.001 ~ P < 0.05）。在判别分析中，在控制父母肥胖后，只有父母相应的疾病被选入模型作为显着的预测因子。在灵敏度方面，54.8%，50.0%，66.7%和69.1%的后代可以正确预测单独的TG/HDL-C，单独的LDL-C，组合，和任何类型的疾病，分别由父母双方的相应疾病。同样，父母的血脂异常，从他们的孩子的disorder.ConclusionThe的可预测性也moderate.ConclusionThe结合血脂异常有家族基础，父母或儿童提供的理由，以确定自己的风险状态，但是，灵敏度和阳性预测值不高，足以作为一个选择性的筛选工具是有用的。
BackgroundThe relationship of dyslipidemias between young offspring and their parents was examined to evaluate its usefulness in predicting lipid disorders among parents and children.MethodsYoung offspring ages 5–17 years and their parents were studied in a community-based sample of 477 families. The dyslipidemias were defined as: (1) isolated high low-density lipoprotein cholesterol (LDL-C); (2) isolated high triglycerides (TG) and/or low high-density lipoprotein cholesterol (HDL-C); and (3) combined, involving both above.ResultsChildren of parents with a given dyslipidemia type had the highest frequency of the same disorder (P< 0.001 toP< 0.05). In discriminant analyses only the corresponding disorders in their parents were selected into the models as significant predictors after controlling parental obesity. In terms of sensitivity, 54.8, 50.0, 66.7, and 69.1% of offspring could be correctly predicted for isolated TG/HDL-C, isolated LDL-C, combined, and any type of disorder, respectively, by the corresponding disorders in both parents. Likewise, the predictability of parents' dyslipidemia from their children's disorder was also modest.ConclusionThe conjoint dyslipidemias have familial basis to provide rationale for parents or children to determine their own risk status; however, sensitivity and positive predictive values are not high enough to be useful as a selective screening tool.