Antibacterial and bioactive composite bone cements containing surface silver-doped glass particles
Antibacterial and bioactive composite bone cements containing surface silver-doped glass particles
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DOI：
10.1088/1748-6041/10/5/055014
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发表时间：
2015-09-01
影响因子：
4
通讯作者：
Verne, Enrica
中科院分区：
文献类型：
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作者：
Miola, Marta;Fucale, Giacomo;Verne, Enrica
采用离子交换法对生物活性硅基玻璃粉（SBA 2）进行了银（Ag+）掺杂。扫描电子显微镜（SEM）、能谱仪（EDS）和X射线衍射仪（XRD）分析表明，玻璃粉中富集了Ag+离子。然而，随着交换溶液中Ag浓度的增加，少量的Ag 2CO 3沉淀。还评价了Ag-SBA 2对金黄色葡萄球菌的最小抑菌浓度（MIC）和最小杀菌浓度（MBC），分别为0.05 mg ml（-1）和0.2 mg ml（-1）。随后，将Ag-SBA 2玻璃用作骨水泥（Simplex（TM）P）的商业配方中的填料（30%wt），以赋予抗菌和生物活性。对复合骨水泥的形态（使用SEM）和成分（使用EDS）进行了研究;玻璃粉末分散良好，并暴露在骨水泥表面。在模拟体液（SBF）中的生物活性测试证明羟基磷灰石在样品表面上的沉淀。复合骨水泥表现出抗菌性能和抗压强度与商业配方相当。
A bioactive silica-based glass powder (SBA2) was doped with silver (Ag+) ions by means of an ionexchange process. Scanning electron microscopy (SEM), energy dispersion spectrometry (EDS) and x-ray diffraction (XRD) evidenced that the glass powder was enriched with Ag+ ions. However, a small amount of Ag2CO3 precipitated with increased Ag concentrations in the exchange solution. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of Ag-SBA2 towards Staphylococcus aureus were also evaluated and were respectively 0.05 mg ml(-1) and 0.2 mg ml(-1). Subsequently, Ag-SBA2 glass was used as filler (30% wt) in a commercial formulation of bone cement (Simplex (TM) P) in order to impart both antibacterial and bioactive properties. The composite bone cement was investigated in terms of morphology (using SEM) and composition (using EDS); the glass powder was well dispersed and exposed on the cement surface. Bioactivity tests in simulated body fluid (SBF) evidenced the precipitation of hydroxyapatite on sample surfaces. Composite cement demonstrated antibacterial properties and a compressive strength comparable to the commercial formulation.