THE PEDIGREE PATTERN OF MATING-TYPE SWITCHING IN SCHIZOSACCHAROMYCES-POMBE
THE PEDIGREE PATTERN OF MATING-TYPE SWITCHING IN SCHIZOSACCHAROMYCES-POMBE
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DOI：
10.1007/bf00417817
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发表时间：
1984-01-01
期刊：
影响因子：
2.5
通讯作者：
EGEL, R
中科院分区：
文献类型：
--
作者：
EGEL, R
The previous observation that in dividing sister cells of S. pombe only 1 of 2 parallel divisions can be accompanied by a switch of mating type, herein termed Miyata''s rule, was confirmed in pedigrees of diploid cells heterozygous for the mat2-Pm-B102 allele. This rule appears to operate at the level of individual chromosomes, since in diploid cells simultaneous single-switch events were frequently observed in both sister cells, albeit on different chromosomes. Assuming 2 successive precursory states for the smt switching signal to the right of mat1, a deterministic 3-step model coupled to the cell cycle was fitted to the empirical frequency distribution of conjugation in 4-lined cells (a minipedigree of dividing sister cells). The nature of the 1st intermediate is still unknown, while the ultimate precursor of a switching event is probably a double-strand cut at smt, which can be revealed by molecular analyses.
