Positive effects of resistance training in frail elderly patients with dementia after long-term physical restraint
Positive effects of resistance training in frail elderly patients with dementia after long-term physical restraint
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DOI：
10.1007/s11357-013-9599-7
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发表时间：
2014-04-01
期刊：
影响因子：
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通讯作者：
Izquierdo, Mikel
中科院分区：
文献类型：
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作者：
Cadore, Eduardo L.;Bays Moneo, Ana B.;Izquierdo, Mikel
本研究调查了长期身体约束后24周停止训练后，多组分运动干预对老年痴呆体弱患者肌肉力量、跌倒发生率和功能结局的影响。18例体弱老年轻度痴呆患者（88.1 +/- 5.1岁）进行了一项多组分锻炼计划，该计划包括4周的步行、平衡和认知锻炼，随后进行4周的阻力运动，每周进行两次[8-12次，每次重复次数为一次重复最大值（1RM）的20- 50%]，结合步行、平衡和认知锻炼。在训练前后以及停止训练24周后，评估力量结果、Barthel指数、平衡、步态能力、从椅子上站起来能力、双重任务表现、跌倒发生率和迷你精神状态检查。在前4周的训练后，只有平衡测试有显著的改善，而没有观察到其他变化。然而，在第二部分训练后，参与者进行time-up-and-go测试所需的时间显著减少（P < 0.05），并改善了等长握力、髋屈曲和膝关节伸展力量以及腿推1RM （P < 0.01）。跌倒的发生率也显著降低（P < 0.01）。在停止训练24周后，几乎所有的物理结果都突然下降（P < 0.05）。运动干预改善了长期肢体约束后体弱老年痴呆患者的力量、平衡和步态能力，而这些益处在训练停止后就消失了。
This study investigated the effects of a multicomponent exercise intervention on muscle strength, incidence of falls and functional outcomes in frail elderly patients with dementia after long-term physical restraint, followed by 24 weeks of training cessation. Eighteen frail elderly patients with mild dementia (88.1 +/- 5.1 years) performed a multicomponent exercise program, which consisted of 4 weeks of walking, balance and cognitive exercises, followed by 4 weeks of resistance exercise performed twice weekly [8-12 repetitions at 20-50 % of the one-repetition maximum (1RM)], combined with walking, balance and cognitive exercises. Before and after training, as well as after 24 weeks of training cessation, strength outcomes, Barthel Index, balance, gait ability, rise from a chair ability, dual task performance, incidence of falls and Mini-Mental State Examination were assessed. After the first 4 weeks of training, there was a significant improvement only in the balance test, whereas no additional changes were observed. However, after the second part of the training, the participants required significantly less time for the time-up-and-go test (P < 0.05), and improved the isometric hand grip, hip flexion and knee extension strength, as well as the leg press 1RM (P < 0.01). A significant reduction was also observed in the incidence of falls (P < 0.01). After 24 weeks of training cessation, abrupt decreases were observed in nearly all of the physical outcomes (P < 0.05). The exercise intervention improved strength, balance and gait ability in frail elderly patients with dementia after long-term physical restraint, and these benefits were lost after training cessation.