Subgingival Microbiome Shifts and Community Dynamics in Periodontal Diseases.
Subgingival Microbiome Shifts and Community Dynamics in Periodontal Diseases.
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DOI：
10.1080/19424396.2016.12221035
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发表时间：
2016-07
期刊：
影响因子：
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通讯作者：
P. Diaz;A. Hoare;B. Hong
中科院分区：
文献类型：
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作者：
P. Diaz;A. Hoare;B. Hong
高通量16S rRNA基因测序允许表征龈下微生物组从健康到牙周炎的变化，识别健康相关、牙周炎相关和核心物种，这些物种在健康到疾病之间保持其比例。牙龈炎的发展也具有明显的变化。微生物组的变化类似于微生物的演替，是种间相互作用和群落适应炎症加剧时不断变化的环境的结果。牙龈炎相关和核心物种被认为是微生物组转变的可能介质。
High-throughput 16S rRNA gene sequencing has allowed the characterization of subgingival microbiome shifts from health to periodontitis identifying health-associated, periodontitis-associated and core species, which preserve their proportions from health to disease. The development of gingivitis is also characterized by distinct shifts. Microbiome shifts resemble microbial successions and result from interspecies interactions and community adaptation to the changing environment as inflammation ensues. Gingivitis-associated and core species are proposed as likely mediators of microbiome transitions.