Kikuchi's disease with leukocytoclastic vasculitis in a 10‐year‐old girl
Kikuchi's disease with leukocytoclastic vasculitis in a 10‐year‐old girl
复制标题
10 岁女孩菊池氏病伴白细胞破碎性血管炎
DOI：
10.1046/j.1442-200x.1999.01059.x
复制
发表时间：
1999
影响因子：
1.4
通讯作者：
Seiichi Hagiwara1 and Yasuo Hosomura
中科院分区：
文献类型：
--
作者：
H. Kawai;M. Hasegawa;Seiichi Hagiwara1 and Yasuo Hosomura
Kikuchi在1972年被认为是一种独立的淋巴结疾病，具有自限性的临床病程该病已在不同地理区域报告，主要在日本，但其病因尚不清楚。组织细胞坏死性淋巴结炎主要发生于成年女性，在儿童中很少见本病的特征性临床症状包括持续发热和无痛性颈淋巴肿大。实验室异常表现包括外周血白细胞减少、血小板减少和红细胞沉降率升高，偶有肝肿大和脾肿大淋巴结活检有典型的组织病理学表现最近，我们遇到了一个孩子，他在组织细胞坏死性淋巴结炎的过程中发生了白细胞破坏性血管炎。组织细胞坏死性淋巴结炎已知可并发荨麻疹、无菌性脑膜炎、小脑性共济失调和自身免疫功能障碍，但以前没有血管炎并发症的报道。我们根据患者的临床过程和包括组织学在内的实验室数据调查了这两种情况的病因。
Kikuchi in 1972 as an independent disease of lymph nodes with a self-limiting clinical course.1 This disease has been reported in different geographic regions, chiefly in Japan, but its etiology remains unknown. Histiocytic necrotizing lymphadenitis occurs predominantly in adult females and is rare in children.2,3 Characteristic clinical symptoms of this disease include persistent fever and painless cervical lymphadenopathy. Abnormal laboratory findings include leukopenia, thrombocytopenia in the peripheral blood and an elevated erythrocyte sedimentation rate, with occasional hepatomegaly and splenomegaly.2 Typical histopathological findings are observed on lymph nodes biopsy.3 Recently, we encountered a child in whom leukocytoclastic vasculitis had occurred during the course of histiocytic necrotizing lymphadenitis. Histiocytic necrotizing lymphadenitis has been known to be complicated with anthema, aseptic meningitis, cerebellar ataxia and autoimmune dysfunctions, but there have been no previous reports of complication with vasculitis. We investigated the etiology of the two conditions in this patient on the basis of her clinical course and laboratory data including histology.
影响因子：
2.3
作者：
R. Dorfman;G. Berry
通讯作者：
R. Dorfman;G. Berry