Ontogeny of the inflammatory response in the fetal rat.
Ontogeny of the inflammatory response in the fetal rat.
复制标题
胎鼠炎症反应的个体发育。
DOI：
10.1159/000241268
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
J. Esterly
中科院分区：
文献类型：
--
作者：
B. Gruber;J. Esterly
妊娠16、17和18天的胎鼠（dg）注射松节油或1%印度墨水中的粪链球菌。注射后24、48和96小时收集腹膜组织和渗出物标本。注射细菌 24 小时后，一些最小的动物 (16 dg) 出现炎症。反应包括腹膜附近组织中多形核（PMN）和单核（MN）细胞的浸润。腹膜腔内还发现了炎症细胞。在这些细胞以及浆膜和邻近间质的细胞中注意到墨水颗粒和细菌的吞噬作用。在同窝对照中未观察到游离腹膜细胞。 48 小时收集的渗出液中的 PMN 和 MN 中也发现了吞噬作用。在注射 17 dg 细菌墨水后 24 小时处死的动物中观察到更明显的粒细胞反应。到 19 dg 时，炎症更加广泛和持续。对松节油的反应与组织切片中观察到的不同程度的组织损伤有关。注射时的孕龄是比病变持续时间更重要的反应程度和特征的决定因素。
Fetal rats of 16, 17 and 18 days gestation (dg) were injected with turpentine or Streptococcus faecalis in 1% India ink. Specimens of peritoneal tissues and exudates were collected at 24, 48 and 96 h after injection. Inflammation was present in some of the youngest animals (16 dg) 24 h after injection with bacteria. The response consisted of infiltrates of polymorphonuclear (PMN) and mononuclear (MN) cells in tissues adjacent to the peritoneum. Inflammatory cells were also found within the peritoneal cavity. Phagocytosis of ink particles and bacteria was noted in these cells and in cells of the serosa and adjacent mesenchyme. Free peritoneal cells were not seen in littermate controls. Phagocytosis was also noted in PMNs and MNs in the exudates collected at 48 h. A more marked granulocytic response was seen in animals sacrificed 24 h following bacteria-ink injection at 17 dg. Inflammation was more extensive and consistent by 19 dg. The reaction to turpentine was associated with the variable degree of tissue injury noted in histologic sections. The gestational age at time of injection was a more important determinant of the magnitude and character of response than was the duration of the lesion.