Cholinergic system function and cognition in mild cognitive impairment
Cholinergic system function and cognition in mild cognitive impairment
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DOI：
10.1016/j.neurobiolaging.2010.08.015
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发表时间：
2012-05-01
影响因子：
4.2
通讯作者：
Heiss, Wolf-Dieter
中科院分区：
文献类型：
--
作者：
Haense, Cathleen;Kalbe, Elke;Heiss, Wolf-Dieter
胆碱能功能障碍在神经退行性疾病如轻度认知障碍（MCI）的早期阶段的证据是不确定的。以前的正电子发射断层扫描（PET）研究基于小样本调查是否与记忆障碍有关。我们研究了皮质乙酰胆碱酯酶（AChE）活性是否在这个阶段降低，并与认知功能相关。应用正电子发射断层显像示踪剂N-[C-11]-甲基-4-哌啶基乙酸酯（[11 C] MP 4A）测定21例正常对照和17例MCI患者脑内AChE活性。使用标准图谱区域分析AChE活性的参数图像。主成分分析（PCA）的AChE活性的区域值和相关性分析与神经心理测试结果进行。皮质AChE活性显示MCI患者与对照组相比，颞叶区最明显的显着下降。他们形成了一个主成分的主要部分，显着相关的语言和非语言记忆，语言理解和执行功能。在MCI的临床阶段，胆碱能功能障碍是甚至在痴呆发作之前的早期标志。它的影响，特别是对颞叶新皮层与受损的神经心理功能。(C)2012 Elsevier Inc. All rights reserved.
Evidence for cholinergic dysfunction in very early stages of neurodegeneration like mild cognitive impairment (MCI) is inconclusive. Previous positron emission tomography (PET) studies based on small samples investigated if it is related to memory impairment. We examined whether cortical acetylcholine esterase (AChE) activity is reduced at this stage and correlated with cognitive function. N-[C-11]-methyl-4-piperidyl acetate ([11C]MP4A), a positron emission tomography tracer for measuring cerebral AChE activity in vivo, was applied in 21 controls and 17 MCI patients. Parametric images of AChE activity were analyzed using standard atlas regions. Principal components analysis (PCA) of regional values of AChE activity and correlation analysis with neuropsychological test results was performed. Cortical AChE activity showed a significant decline in MCI patients compared with controls which was most pronounced in temporal regions. They formed the main part of a principal component that was related significantly to verbal and nonverbal memory, language comprehension and executive function. Cholinergic dysfunction is an early hallmark even before onset of dementia at the clinical stage of MCI. Its impact especially on temporal neocortex is associated with impaired neuropsychological function. (C) 2012 Elsevier Inc. All rights reserved.