A systems biology approach to infectious disease research: innovating the pathogen-host research paradigm.
A systems biology approach to infectious disease research: innovating the pathogen-host research paradigm.
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DOI：
10.1128/mbio.00325-10
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发表时间：
2011-03-01
期刊：
影响因子：
6.4
通讯作者：
Katze MG
中科院分区：
文献类型：
--
作者：
Aderem A;Adkins JN;Ansong C;Galagan J;Kaiser S;Korth MJ;Law GL;McDermott JG;Proll SC;Rosenberger C;Schoolnik G;Katze MG
20世纪的标志是我们对微生物和传染病的认识取得了非凡的进步，但大流行病仍然存在，食物和水传播疾病频繁发生，多重耐药微生物正在增加，所需的药物和疫苗尚未开发出来。过去的科学方法--包括对分子生物学中典型的单个基因和蛋白质的高度关注--不足以应对这些挑战。21世纪的第一个十年见证了技术和计算方法的显著创新。这些新工具提供了复杂生物系统的几乎全面的观点，并可以提供病原体-宿主相互作用的相应更深入的了解。为了充分利用这些创新，国家过敏和传染病研究所最近启动了传染病研究系统生物学计划。作为系统生物学计划的参与者，我们认为是时候重新定义病原体-宿主研究范式了。
The twentieth century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and waterborne illnesses are frequent, multidrug-resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the past—including the intense focus on individual genes and proteins typical of molecular biology—have not been sufficient to address these challenges. The first decade of the twenty-first century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program, we think that the time is at hand to redefine the pathogen-host research paradigm.