BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex
BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex
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DOI：
10.1016/s0165-3806(02)00540-0
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发表时间：
2002-12-15
期刊：
影响因子：
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通讯作者：
Kleinman, JE
中科院分区：
文献类型：
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作者：
Webster, MJ;Weickert, CS;Kleinman, JE
脑源性神经营养因子（Brain derived neurotrophic factor，BDNF）广泛分布于中枢神经系统（central nervous system，CNS），对多种CNS神经元具有促进存活的作用。我们已经研究了BDNF mRNA表达水平的变化，在背外侧前额叶皮层（DLPFC）的出生后的人的大脑使用RNA酶保护试验和原位杂交。将DLPFC中的BDNF mRNA表达与枕叶皮质中的BDNF mRNA表达进行比较。脑源性神经营养因子的mRNA水平各层之间的变化，与第VI层始终高于其他层的DLPFC和枕区。BDNF mRNA水平从婴儿期到成年期增加约三分之一，即它们在婴儿期和青春期相对较低，在青年期达到峰值，并在整个成年期和衰老期间保持恒定水平。在DLPFC的BDNF mRNA水平的显着增加，在年轻的成年期与额叶皮质成熟的时间在结构和功能。在人类发育的这个关键时期，BDNF的增加可能对这段时间出现的严重精神障碍的病因学和治疗有重要意义。出版社：Elsevier Science B.V.
Brain derived neurotrophic factor (BDNF) is widely distributed in the central nervous system (CNS) and has survival-promoting actions on a variety of CNS neurons. We have examined changes in the level of BDNF mRNA expression in the dorsolateral prefrontal cortex (DLPFC) of the postnatal human brain using both RNAse protection assay and in situ hybridization. Expression of BDNF mRNA in the DLPFC was compared to that in the occipital cortex. BDNF mRNA levels vary between layers, with layer VI consistently higher than other layers in both the DLPFC and occipital regions. BDNF mRNA levels increase approximately one-third from infancy to adulthood, i.e. they are relatively low during infancy and adolescence, peak during young adulthood, and are maintained at a constant level throughout adulthood and aging. The significant increase in BDNF mRNA levels in the DLPFC during the young adult period coincides with the time when the frontal cortex matures both structurally and functionally. The increase in BDNF at this critical time in human development may have important implications for the etiology and treatment of the severe mental disorders that tend to present during this time. Published by Elsevier Science B.V.