Hepatitis B genotypes and the response to interferon therapy
Hepatitis B genotypes and the response to interferon therapy
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DOI：
10.1016/s0168-8278(00)80135-x
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发表时间：
2000-12-01
影响因子：
25.7
通讯作者：
Chen, DS
中科院分区：
文献类型：
--
作者：
Kao, JH;Wu, NH;Chen, DS
背景/目标：已观察到不同B型肝炎病毒（HBV）基因型之间可能存在致病性差异;然而，HBV基因型之间对干扰素治疗的反应仍不清楚。方法：回顾性分析58例经干扰素α-2b治疗的B、C基因型慢性乙型肝炎患者的临床资料。以治疗48周后血清转氨酶水平恢复正常、B e抗原和HBV DNA转阴为干扰素治疗的疗效指标。而C基因型患者血清氨基转移酶水平较高，核心启动子突变频率较高，B基因型和C基因型患者的有效率分别为41%和15%，在血清转氨酶水平较高的患者中，应答率分别为50%和17%（p=0.025）。此外，年龄较小和基因型B感染可能预示着对干扰素α的反应更好。结论：与基因型B相比，HBV基因型C与核心启动子突变频率较高和对干扰素α治疗的反应率较低相关。
Background/Aims: Possible pathogenic differences among hepatitis B virus (HBV) genotypes have been observed; however, the response to interferon therapy among HBV genotypes remains unknown. We therefore analyzed the efficacy of interferon alfa in the treatment of chronic hepatitis B patients with different HBV genotypes,Methods: Fifty-eight genotype B or C infected chronic hepatitis B patients who had been treated with interferon alfa-2b were retrospectively studied. The response to interferon was defined as normalization of serum aminotransferase level, loss of hepatitis B e antigen and HBV DNA 48 weeks post-treatment,Results: Baseline data of both groups of patients were comparable; however, genotype C patients had a higher serum aminotransferase level and a higher frequency of core promoter mutation, The response rate was 41% and 15% in genotype B and C patients, respectively (p=0.045), In those with higher serum aminotransferase levels, the response rate was 50% and 17%, respectively (p=0.025). Additionally, younger age and genotype B infection may predict a better response to interferon alfa,Conclusions: HBV genotype C, compared to genotype B, is associated with a higher frequency of core promoter mutation, and a lower response rate to interferon alfa therapy.