Immunobiology of endometriosis
Immunobiology of endometriosis
复制标题
DOI：
10.1016/s0015-0282(00)01630-7
复制
发表时间：
2001-01-01
影响因子：
6.7
通讯作者：
Taylor, RN
中科院分区：
文献类型：
--
作者：
Lebovic, DI;Mueller, MD;Taylor, RN
目的：目的：综述子宫内膜异位症的体液和细胞免疫学，并讨论未来诊断和治疗方法的基本原理。设计：文献调查。结果：注定发展为子宫内膜异位症的妇女，免疫监测缺陷可能会使异位子宫内膜组织存活。证据包括子宫内膜细胞对凋亡的抵抗，可能是通过分泌干扰基质细胞对植入物识别和/或FasL表达的蛋白质，诱导Fas免疫细胞的凋亡。虽然免疫反应可能是有缺陷的，但它的某些方面在子宫内膜异位症中明显增强，如通过广义多克隆B细胞自身免疫激活和免疫蛋白分泌所见。子宫内膜异位症患者体内多种细胞因子、趋化因子和生长因子（包括血管生长因子）的表达增加，局部产生的细胞因子的复杂网络调节异位子宫内膜种植体的生长和炎症行为。来自子宫内膜异位症病灶的促炎蛋白和相关的免疫细胞有助于增强与子宫内膜异位症相关的炎症反应，从而使这些病灶存活，而不是导致其死亡。(C)2001年，美国生殖医学会。
Objective: To provide a review of the humoral and cellular immunology of endometriosis and to discuss the rationale for future approaches to diagnosis and treatment.Design: Literature survey.Result(s): Defective immunosurveillance in women who are destined to develop endometriosis may allow for the survival of ectopic endometrial tissue. The evidence includes endometrial cell resistance to apoptosis, perhaps through the secretion of proteins that interfere with implant recognition and/or FasL expression by stromal cells, inducing apoptosis of Fas-bearing immune cells. Although the immune response may be defective, aspects of it clearly are enhanced in endometriosis, as is seen by the generalized polyclonal B-cell autoimmune activation and secretion of immune proteins. Several cytokines, chemokines, and growth factors (including vascular growth factors) are increased in women with endometriosis.Conclusion(s): A complex network of locally produced cytokines modulate the growth and inflammatory behavior of ectopic endometrial implants. Proinflammatory proteins from endometriotic lesions-and associated immune cells contribute to the enhanced inflammatory reaction associated with endometriosis that subserves the survival of these lesions instead of leading to their demise. (C) 2001 by American Society for Reproductive Medicine.