Health-related quality of life for nasopharyngeal carcinoma patients with cancer-free survival after treatment
Health-related quality of life for nasopharyngeal carcinoma patients with cancer-free survival after treatment
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DOI：
10.1016/s0360-3016(02)02838-9
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发表时间：
2002-07-15
影响因子：
7
通讯作者：
Hsu, HC
中科院分区：
文献类型：
--
作者：
Fang, FM;Chiu, HC;Hsu, HC
目的：为评价鼻咽癌（NPC）患者治疗后无癌生存期的健康相关生活质量（HR-QOL），并探讨影响其HR-QOL的相关因素。同样数量的没有癌症史的人来医院进行健康检查的数据也被收集起来进行比较。所有受试者在门诊自报中文SF-36问卷和9个头颈部功能障碍（HNFI）项目。结果：中国台湾地区使用的SF-36量表具有良好的内部信度（Cronbach's alpha：0.87-0.96）和区分效度。NPC生存者SF-36的大部分功能领域和所有9个HNFI项目均显著差于对照组。对于NPC幸存者，没有癌症或治疗相关变量与SF-36的任何功能域或HNFI的任何项目显著相关。经济状况、文化程度、职业状况和合并症的数量是与NPC幸存者SF-36大多数功能领域显著相关的变量。SF-36显示，经济状况较好、受教育程度较高、有工作或无合并症的患者HR-QOL较好。唾液分泌、听力和吞咽功能障碍是困扰NPC幸存者的前三位HNFI。经济状况仍然是与HNFI相关的最重要的变量，包括流涎，吞咽，颈部僵硬，味觉和发声。经济状况较好的生存者报告的HNFI较轻。结论：NPC生存者的HR-QOL比健康对照组的研究。社会经济状况是与NPC生存者HR-QOL相关最显著的变量。这一结果可能表明，患者的上级个人特征和经济资源是决定他们科普癌症和影响其HR-QOL的治疗并发症的能力的重要变量。(C)2002年爱思唯尔科学公司
Purpose: To evaluate the health-related quality of life (HR-QOL) of nasopharyngeal cancer (NPC) patients with cancer-free survival after treatment and to investigate the factors correlated with their HR-QOL.Methods and Materials: One hundred eighty-two NPC patients with cancer-free survival of more than 2 years after treatment were enrolled in the study. Data from the same number of people without a history of cancer, who had come to the hospital for health checkups, were also collected for comparison. The Chinese SF-36 questionnaire and nine items about head-and-neck functional impairments (HNFI) were self-reported by all participants at the clinics. Data relating to sociodemograpbic factors, cancer stage, and treatment of NPC survivors were analyzed.Results: Psychometric tests revealed the excellent internal reliability (Cronbach's alpha: 0.87-0.96) and discriminative validity of the Chinese SF-36 used in Taiwan. Most functional domains of the Chinese SF-36 and all nine HNFI items were significantly worse in NPC survivors than in control subjects. No cancer or treatment-related variables significantly correlated with any functional domains of SF-36 or any items of HNFI for NPC survivors. Economic status, educational level, occupational status, and the number of comorbidities were the variables that significantly correlated with most functional domains of SF-36 for NPC survivors. Patients with more sufficient economic status, higher educational levels, with employment, or without comorbidity tended to enjoy better HR-QOL as detected by the SF-36. Salivation, hearing, and swallowing dysfunctions were the top three HNFI that disturbed NPC survivors. Economic status remained the most significant variable correlated with HNFI, including salivation, swallowing, neck stiffness, taste, and phonation. Survivors with better economic status reported less severe HNFI.Conclusions: NPC survivors had worse HR-QOL than healthy control subjects in the study. Socioeconomic status was the most significant variable that correlated with the HR-QOL of NPC survivors. This result might indicate that patients' superior individual characteristics and financial resources are important variables determining their ability to cope with cancer and treatment complications affecting their HR-QOL. (C) 2002 Elsevier Science Inc.