INFLUENCE OF CHROMIUM, CADMIUM, AND LEAD ON RAT AORTIC LIPIDS AND CIRCULATING CHOLESTEROL.
INFLUENCE OF CHROMIUM, CADMIUM, AND LEAD ON RAT AORTIC LIPIDS AND CIRCULATING CHOLESTEROL.
复制标题
铬、镉和铅对大鼠主动脉脂质和循环胆固醇的影响。
DOI：
10.1152/ajplegacy.1965.209.2.433
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发表时间：
1965
期刊：
影响因子：
--
通讯作者：
J. J. Balassa
中科院分区：
文献类型：
--
作者：
H. Schroeder;J. J. Balassa
雄性和雌性大鼠从断奶到死亡，在饮用水中摄入5ppm的铅、镉和铬(III)，饮食中这些金属含量不足或低。在两个年龄段，男性在每种金属上的平均血清胆固醇低于对照组；女性在铅和铬上的水平高于对照组。随着年龄的增长，男性和女性的镉摄入量都增加了31%。染镉、铅组大鼠主动脉嗜苏丹红染(苏丹红IV染色)较对照组和铬组大鼠明显增多。可提取的主动脉脂类在镉喂养的动物中最高。在荧光灯下可见的斑块，在铅组、镉组和对照组的165个主动脉中有31个出现，在48个铬组中有1个。服用镉的大鼠循环胆固醇降低与主动脉脂质升高有关。
Male and female rats were given 5 ppm lead, cadmium, and chromium (III) in drinking water from the time of weaning until death, on a diet deficient or low in these metals. Mean serum cholesterol of males on each metal was lower than that of controls at two ages; levels of females on lead and chromium were higher. A 31% increase occurred with age in both sexes on cadmium. There was more sudanophilia (staining with Sudan IV) in aortas of rats on cadmium and lead than in the controls and the chromium fed. Extractable aortic lipids were highest in cadmium-fed animals. Plaques, visible under fluorescent light, were present in 31 of 165 aortas from the lead, cadmium, and control groups and 1 of 48 from the chromium. Lowered circulating cholesterol was associated with increased aortic lipid in rats given cadmium.