Human spiral artery renin-angiotensin system
Human spiral artery renin-angiotensin system
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DOI：
10.1161/01.hyp.32.4.683
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发表时间：
1998-10-01
期刊：
影响因子：
8.3
通讯作者：
Ward, K
中科院分区：
文献类型：
--
作者：
Morgan, T;Craven, C;Ward, K
妊娠引起子宫螺旋动脉重塑为扩张的子宫胎盘血管，其机制尚不清楚，称为“生理变化”。然而，在患有先兆子痫的妇女中，许多螺旋动脉保持不变或发展为中膜增生和动脉粥样硬化。我们最近证实血管紧张素原通过重塑妊娠早期蜕膜的螺旋动脉表达。我们推测，局部螺旋动脉肾素-血管紧张素系统介导妊娠诱导的这些血管的重塑。在这项研究中，我们测试了表达的肾素，血管紧张素转换酶，血管紧张素II 1型受体基因在孕早期子宫使用逆转录聚合酶链反应。通过原位杂交和免疫组织化学定位表达。肾素、血管紧张素转换酶和血管紧张素II 1型受体都在重塑螺旋动脉内和周围表达。这些观察结果表明，局部螺旋动脉肾素-血管紧张素系统可能在妊娠诱导的这些血管重塑中发挥作用。血管紧张素原启动子A（-6）变异纯合子妇女血管紧张素原表达升高可能促进异常重塑，而G（-6）纯合子妇女血管紧张素原表达水平相对较低可能允许足够的正常重塑，以保护这些妇女免于先兆子痫。
Pregnancy induces uterine spiral arteries to remodel into dilated uteroplacental vessels by an unknown mechanism called "physiological change." In women who develop preeclampsia, however, many spiral arteries remain unchanged or develop medial hyperplasia and atherosis. We recently demonstrated that angiotensinogen is expressed by remodeling spiral arteries in first-trimester decidua. We hypothesize that a local spiral artery renin-angiotensin system mediates pregnancy-induced remodeling of these vessels. In this study we tested for expression of renin, angiotensin-converting enzyme, and angiotensin II type 1 receptor genes in the first-trimester uterus using reverse-transcription polymerase chain reaction. Expression was localized by in situ hybridization and immunohistochemistry. Renin, angiotensin-converting enzyme, and the angiotensin II type 1 receptor are all expressed in and around remodeling spiral arteries. These observations suggest that a local spiral artery renin-angiotensin system may play a role in pregnancy-induced remodeling of these vessels. Elevated angiotensinogen expression in women homozygous for the A(-6) variant in the angiotensinogen promoter may promote abnormal remodeling, whereas relatively lower levels in women homozygous for G(-6) may permit enough normal remodeling to protect these women from preeclampsia.