Optical measurement of arterial mechanical properties: from atherosclerotic plaque initiation to rupture.
Optical measurement of arterial mechanical properties: from atherosclerotic plaque initiation to rupture.
复制标题
动脉机械特性的光学测量：从动脉粥样硬化斑块开始到破裂。
DOI：
10.1117/1.jbo.18.12.121507
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发表时间：
2013
影响因子：
3.5
通讯作者：
Nadkarni,SeemantiniK
中科院分区：
文献类型：
--
作者：
Nadkarni,SeemantiniK
在冠状动脉粥样硬化的发病过程中，从病变开始到破裂，动脉的力学特性被许多细胞、分子和血液动力学过程改变。越来越多的人认识到，机械因素可以主动驱动血管细胞信号传导并调节动脉粥样硬化疾病的进展。在晚期斑块中，动脉粥样硬化的机械性质影响纤维帽中的应力分布并介导斑块破裂，从而导致急性冠状动脉事件。这篇综述文章探讨了目前的光学技术，提供信息的动脉组织的机械性能，以促进我们的理解动脉粥样硬化的发展，导致斑块破裂的机械因素。讨论的光学方法包括光学微流变学和牵引力显微镜，探测单细胞和细胞外基质成分的机械行为，和血管内成像方式，包括激光散斑流变学，光学相干弹性成像，偏振敏感光学相干断层扫描测量先进冠状动脉病变的机械性能。鉴于这些技术可以提供丰富的信息，光学成像模式有望在未来阐明冠状动脉粥样硬化的机械方面发挥越来越重要的作用。
During the pathogenesis of coronary atherosclerosis, from lesion initiation to rupture, arterial mechanical properties are altered by a number of cellular, molecular, and hemodynamic processes. There is growing recognition that mechanical factors may actively drive vascular cell signaling and regulate atherosclerosis disease progression. In advanced plaques, the mechanical properties of the atheroma influence stress distributions in the fibrous cap and mediate plaque rupture resulting in acute coronary events. This review paper explores current optical technologies that provide information on the mechanical properties of arterial tissue to advance our understanding of the mechanical factors involved in atherosclerosis development leading to plaque rupture. The optical approaches discussed include optical microrheology and traction force microscopy that probe the mechanical behavior of single cell and extracellular matrix components, and intravascular imaging modalities including laser speckle rheology, optical coherence elastography, and polarization-sensitive optical coherence tomography to measure the mechanical properties of advanced coronary lesions. Given the wealth of information that these techniques can provide, optical imaging modalities are poised to play an increasingly significant role in elucidating the mechanical aspects of coronary atherosclerosis in the future.