Frailty and quality of life in elderly patients with acute coronary syndrome.
Frailty and quality of life in elderly patients with acute coronary syndrome.
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DOI：
10.2147/cia.s99842
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发表时间：
2016
影响因子：
3.6
通讯作者：
Wontor R
中科院分区：
文献类型：
--
作者：
Lisiak M;Uchmanowicz I;Wontor R
虚弱的老年人有可能出现不利的健康结果，如残疾、住院和死亡。近年来，文献已引起注意的脆弱综合征（FS）在急性冠状动脉综合征（ACS）的作用。很少有研究两个多维变量之间的关系，如FS和生活质量（QoL）。本研究的目的是探讨老年ACS患者（≥65岁）FS与早期生活质量的关系。该研究在91名65岁及以上ACS患者中进行。使用MacNew问卷评价QoL，使用蒂尔堡虚弱指标评价虚弱。82.4%的患者存在FS。平均蒂尔堡虚弱指标评分为7.43±2.57。FS和QoL的总体值之间呈负相关（r=-0.549，P<0.05）。对早期生活质量产生负面影响的脆弱性因素有：FS、婚姻状况、保守治疗和高血压。在多变量分析中，发现FS是较差QoL的独立预测因子（β ±标准误-0.277 ±0.122，P=0.026）。FS的存在对ACS患者的早期生活质量有负面影响。这项研究表明，在老年ACS患者中，有必要识别虚弱，以便在ACS中实施额外的治疗和护理策略。
Frail elderly people are at risk of developing adverse health outcomes such as disability, hospitalization, and mortality. In recent years, the literature has drawn attention to the role of frailty syndrome (FS) in acute coronary syndrome (ACS). There are few studies regarding the relationship between two multidimensional variables such as FS and quality of life (QoL). The aim of the study was to investigate the relationship between FS and early QoL of elderly patients with ACS (≥65 years old). The study was conducted among 91 patients aged 65 years and over with ACS. The MacNew questionnaire was used to evaluate QoL and the Tilburg frailty indicator to evaluate frailty. FS was present in 82.4% of patients. The average Tilburg frailty indicator score was 7.43±2.57. A negative correlation between the global values of FS and QoL was shown (r=−0.549, P<0.05). The vulnerability factors that negatively affected early QoL were: FS, marital status, conservative therapy, and hypertension. In multivariate analysis, FS was found to be the independent predictor of worse QoL (β ± standard error −0.277±0.122, P=0.026). The presence of FS has a negative impact on early QoL in patients with ACS. The study suggests that in elderly patients with ACS, there is a need to identify frailty in order to implement additional therapeutic and nursing strategies in ACS.