Bioactive flavones and biflavones from Selaginella moellendorffii Hieron
Bioactive flavones and biflavones from Selaginella moellendorffii Hieron
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DOI：
10.1016/j.fitote.2009.09.007
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发表时间：
2010-06-01
期刊：
影响因子：
3.4
通讯作者：
Wang, Qiang
中科院分区：
文献类型：
--
作者：
Cao, Yuan;Tan, Nin-Hua;Wang, Qiang
从江南卷柏（Selaginella moellendorffii Hieron.）中分得3个新黄酮类化合物，分别命名为5-羧甲基-4 '，7-二羟基黄酮（1）、其乙酯（2）和丁酯（3）。以及10种已知化合物。根据光谱和化学分析鉴定了它们的结构。评价所选化合物的抗HBV和细胞毒活性。其中，化合物2和3在体外对Hep G2.2.15细胞系的B型肝炎病毒（HBV）表面抗原（HBsAg）分泌显示抑制活性，IC 50值分别为0.17 mg/ml和0.46 mg/ml，对HBV e抗原（HBeAg）分泌显示抑制活性，IC 50值分别为0.42 mg/ml和0.42 mg/ml。化合物7.8. 10和12对所测试的三种人癌细胞系表现出选择性细胞毒性。(C)2009 Elsevier By. All rights reserved.
Three new flavones named 5-carboxymethyl-4',7-dihydroxyflavone (1), its ethyl ester (2) and butyl ester (3) were isolated from the herb Selaginella moellendorffii Hieron., together with ten known compounds. Their structures were elucidated on the basis of spectroscopic and chemical analysis. Selected compounds were evaluated for their anti-HBV and cytotoxic activity. Among them, compounds 2 and 3 displayed inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC50 values of 0.17 mg/ml and 0.46 mg/ml, and on HBV e antigen (HBeAg) secretion with IC50 values of 0.42 mg/ml and 0.42 mg/ml, respectively. Compounds 7.8. 10 and 12 exhibited selective cytotoxicity against the three human cancer cell lines tested. (C) 2009 Elsevier By. All rights reserved.