Spectral domain detection in low-coherence spectroscopy.
Spectral domain detection in low-coherence spectroscopy.
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DOI：
10.1364/boe.3.002263
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发表时间：
2012-09-01
影响因子：
3.4
通讯作者：
Faber DJ
中科院分区：
文献类型：
--
作者：
Bosschaart N;Aalders MC;van Leeuwen TG;Faber DJ
低相干光谱（LCS）提供了在尺寸和深度都可控的所选组织体积内测量定量和波长分辨光学性质光谱的有价值的可能性。到目前为止，只有时域检测研究LCS（tdLCS），但频谱域检测提供了理论上的速度/灵敏度优于tdLCS。在这篇文章中，我们介绍了一种在LCS（sdLCS）中进行谱域检测的方法，该方法具有作为测量深度的函数的最佳灵敏度。我们验证我们的方法在模拟计算和实验上的幻影与已知的光学特性。由sdLCS测量的体模的衰减、吸收和散射系数光谱与预期的光学特性和由tdLCS测量的光学特性一致。
Low-coherence spectroscopy (LCS) offers the valuable possibility to measure quantitative and wavelength resolved optical property spectra within a tissue volume of choice that is controllable both in size and in depth. Until now, only time domain detection was investigated for LCS (tdLCS), but spectral domain detection offers a theoretical speed/sensitivity advantage over tdLCS. In this article, we introduce a method for spectral domain detection in LCS (sdLCS), with optimal sensitivity as a function of measurement depth. We validate our method computationally in a simulation and experimentally on a phantom with known optical properties. The attenuation, absorption and scattering coefficient spectra from the phantom that were measured by sdLCS agree well with the expected optical properties and the measured optical properties by tdLCS.