Efficacy of Low-Dose Human Chorionic Gonadotropin Therapy in Dogs with Spermatogenic Dysfunction: A Preliminary Study
Efficacy of Low-Dose Human Chorionic Gonadotropin Therapy in Dogs with Spermatogenic Dysfunction: A Preliminary Study
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低剂量人绒毛膜促性腺激素治疗生精功能障碍犬的疗效：初步研究
DOI：
10.1111/rda.12366
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发表时间：
2014
影响因子：
1.7
通讯作者：
Eiichi Kawakami
中科院分区：
文献类型：
--
作者：
Masanori Kobayashi;Tatsuya Hori;Eiichi Kawakami
人绒毛膜促性腺激素（hCG）是一种糖蛋白，用于治疗生精功能障碍。然而，以前在狗身上进行的研究表明，重复给予大剂量hCG会产生抗hCG的抗体。在这项研究中，我们检查了低剂量注射hCG在4只生精功能障碍和低血浆睾酮（T）水平的雄性犬中的疗效。我们给每只动物注射100 IU hCG，间隔3天5次，并评估精液质量和血浆T水平的变化。在第一次注射hCG后3-5周，4只犬中有3只的射精精子总数、运动精子百分比和血浆T水平增加，但第4只犬无变化。这些结果表明，5次低剂量hCG注射后，生精功能障碍和血浆T水平低的犬的精液质量可能会暂时改善。
ContentsHuman chorionic gonadotropin (hCG) is a glycoprotein used in the treatment of spermatogenic dysfunction. However, previous studies performed in dogs show that repeated administration of large doses of hCG produces antibodies against hCG. In this study, we examined the efficacy of low‐dose injections of hCG in four male dogs with spermatogenic dysfunction and low plasma testosterone (T) levels. We administered 100 IU hCG per animal, five times at 3‐day intervals, and evaluated the changes in semen quality and plasma T levels. The total number of sperm in ejaculate, the percentage of progressively motile sperm and the plasma T levels had increased by 3–5 weeks after the first injection of hCG in three of the four dogs, but were unchanged in the fourth dog. These findings indicate that temporary improvement of the semen quality of dogs with spermatogenic dysfunction and low plasma T levels is possible after five low‐dose injections of hCG.