DENERVATION INCREASES CLENBUTEROL SENSITIVITY IN MUSCLE FROM YOUNG-RATS
DENERVATION INCREASES CLENBUTEROL SENSITIVITY IN MUSCLE FROM YOUNG-RATS
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DOI：
10.1002/mus.880150210
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发表时间：
1992-02-01
期刊：
影响因子：
3.4
通讯作者：
BAILLIE, AGS
中科院分区：
文献类型：
--
作者：
MALTIN, CA;DELDAY, MI;BAILLIE, AGS
克仑特罗已被证明可以改善去神经支配引起的萎缩，因此，在治疗人类肌肉萎缩方面显然具有治疗潜力。以前的研究在大鼠身上使用的剂量在临床实践中是不可接受的，但目前的结果表明，去神经支配的肌肉比神经支配的肌肉或心肌对药物更敏感。在10 μ g/kg体重剂量下，去神经支配肌肉纤维肥大，蛋白质和RNA含量增加，而神经支配肌肉则无此现象。当考虑到代谢体重的基础上，大鼠的有效剂量和人体的“安全”剂量惊人地相似。观察结果表明，有充分的理由假设克仑特罗可以有效地改善人类类似的消瘦状况。
Clenbuterol has been shown to ameliorate denervation-induced atrophy and, therefore, clearly has therapeutic potential in the treatment of muscle wasting conditions in man. Previous studies have used dosages in rats which would be unacceptable in clinical practice, but the present results show that denervated muscle has a greater sensitivity to the drug than innervated or cardiac muscle. Fiber hypertrophy and an increase in protein and RNA content could be observed in denervated muscles but not in innervated muscles at a dose of 10-mu-g/kg body weight. When considered on a metabolic body weight basis, the effective dose in rats and the "safe" dose in man are surprisingly comparable. The observations imply that there is good reason to suppose that clenbuterol could be effective in ameliorating similar wasting conditions in man.