Protective role of DL-α-lipoic acid against mercury-induced neural lipid peroxidation
Protective role of DL-α-lipoic acid against mercury-induced neural lipid peroxidation
复制标题
DOI：
10.1006/phrs.1998.0408
复制
发表时间：
1999-01-01
影响因子：
9.3
通讯作者：
Varalakshmi, P
中科院分区：
文献类型：
--
作者：
Anuradha, B;Varalakshmi, P
通过肌肉注射氯化汞在大鼠模型中诱导实验性神经毒性。DL-α-硫辛酸在三种实验设计方案中作为解毒剂给药。设计了两种短期汞暴露方案，一种是预防性治疗，另一种是治疗性治疗。第三个协议是与预防性治疗的硫辛酸对长期接触汞。中毒组大鼠大脑皮层、小脑和坐骨神经脂质过氧化反应增强，非酶抗氧化状态下降，酶抗氧化状态紊乱。在神经组织中建立了硫辛酸对抗氧化状态的改善作用及其在各种治疗模式期间的治疗功效。(C)1999年意大利药理学会。
Experimental neurotoxicity in rat models was induced by an intramuscular injection of mercuric chloride. DL-alpha-lipoic acid was administered as an antidote in three protocols of experimental design. Two protocols of short-term exposure of mercury was designed, one with prophylactic therapy and the other with curative therapy of lipoic acid. The third protocol was with prophylactic therapy of lipoic acid on long-term exposure of mercury. Enhanced lipid peroxidation, depleted non-enzymic and perturbed enzymic antioxidant status were observed in cerebral cortex, cerebellum and sciatic nerves of the toxic groups. The ameliorating effect of lipoic acid and its therapeutic efficacy during various modes of therapy, on the antioxidant status was established in the nervous tissues. (C) 1999 The Italian Pharmacological Society.