GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo.
GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo.
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DOI：
10.4049/jimmunol.1501582
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Butcher GW
中科院分区：
文献类型：
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作者：
Webb LM;Datta P;Bell SE;Kitamura D;Turner M;Butcher GW
一个有效的免疫系统依赖于淋巴细胞功能和体内平衡的调节。近年来，免疫相关蛋白（GIMAP）家族的GTPases成员被提出调节T细胞稳态。相比之下，人们对它们在B细胞中的功能和作用方式知之甚少。我们已经使用转基因小鼠和体内和体外技术相结合，有条件地和选择性地消融静止和激活的外周B细胞中的GIMAP1。我们的数据表明GIMAP1对于外周B细胞的存活是绝对必要的，无论它们的激活状态如何。加上最近的数据显示GIMAP1在B细胞淋巴瘤中的表达增加，我们的工作指出GIMAP1可能作为多种B细胞介导疾病的操纵靶点。
An effective immune system depends upon regulation of lymphocyte function and homeostasis. In recent years members of the GTPases of the Immune Associated Protein (GIMAP) family have been proposed to regulate T cell homeostasis. In contrast, little is known about their function and mode of action in B cells. We have used a combination of transgenic mice and in vivo and in vitro techniques to conditionally and electively ablate GIMAP1 in resting and activated peripheral B cells. Our data suggest that GIMAP1 is absolutely essential for the survival of peripheral B cells, irrespective of their activation state. Together with recent data showing increased expression of GIMAP1 in B cell lymphomas, our work points to the possible potential of GIMAP1 as a target for manipulation in a variety of B cell-mediated diseases.