ELECTROENCEPHALOGRAPHIC (EEG) SLEEP RECOVERY FOLLOWING PROLONGED ALCOHOL INTOXICATION IN ALCOHOLICS
ELECTROENCEPHALOGRAPHIC (EEG) SLEEP RECOVERY FOLLOWING PROLONGED ALCOHOL INTOXICATION IN ALCOHOLICS
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DOI：
10.1097/00005053-197112000-00005
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发表时间：
1971-01-01
影响因子：
1.9
通讯作者：
MCINTOSH, M
中科院分区：
文献类型：
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作者：
ALLEN, RP;WAGMAN, A;MCINTOSH, M
长期酗酒者的睡眠数据表明，睡眠障碍是酒精解毒的一个重要方面。以前的研究因饮食不佳、戒断发作时间不确定或控制戒断的时间表有限等问题而复杂化。本研究提供了6例因急性酒精解毒而入院的年轻男性患者的纵向数据。其中5例患者在退出前给予充足的饮食和大剂量的酒精维持3至7天;第6例患者在入院时立即退出病房。睡眠被记录为每个24小时的时间超过2周，睡眠的控制标准被设置为每个病人从6天后的一段时间内停止饮酒。数据表明，酒精戒断的恢复时间约为6至8天。在恢复过程中，快速眼动（REM）睡眠经历阻尼振荡，而觉醒百分比和入睡时间缓慢下降到对照水平。慢波睡眠缺乏或异常低。第6例患者在入院时没有控制饮食或酒精量而退出，表现出最大的REM反弹，但在所有其他方面的结果与其他患者相似。这表明，在这6 - 8天的解毒期间，酗酒者为了减少快速眼动睡眠障碍而恢复饮酒的风险增加。
Sleep data from chronic alcoholics have indicated that sleep disturbance represents an important aspect of alcoholic detoxification. Previous studies have been complicated by problems of poor diet, uncertain time for onset of withdrawal, or a limited time schedule for controlled withdrawal. This study presents longitudinal data for 6, young adult, male patients who were admitted for acute alcoholic detoxification. Five of these patients were given an adequate diet and a large maintenance dose of alcohol for 3 to 7 days prior to withdrawal; the 6th patient was withdrawn immediately on admission to the ward. Sleep was recorded for each 24-hour period for more than 2 weeks and a control standard of sleep was set for each patient from a period after 6 days off alcohol. The data indicate that the recovery time for alcohol withdrawal is approximately 6 to 8 days. During recovery, rapid eye movement (REM) sleep undergoes a damped oscillation, while percentage of wake and time to sleep onset decrease slowly to the control levels. Slow wave sleep was absent or abnormally low. The 6th patient withdrawn on admission without control of diet or amount of alcohol showed the largest REM rebound, but in all other respects gave results similar to the other patients. It is suggested that during this 6− to 8-day detoxification period the alcoholic has an increased risk of resuming drinking in order to reduce his REM sleep disturbance.