The maintenance of genetic variability by mutation in a polygenic character with linked loci.
The maintenance of genetic variability by mutation in a polygenic character with linked loci.
复制标题
通过连锁基因座多基因特征的突变来维持遗传变异性。
DOI：
10.1017/s0016672308009555
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
R. Lande
中科院分区：
文献类型：
--
作者：
R. Lande
假定在稳定选择下的性状是由n个连锁的、具有加性效应的可变基因座和每个基因座上许多可能的等位基因效应在遗传上决定的。这类系统的一般定性特征是，如果连锁不是很紧密，则性状的遗传方差与基因座的连锁图无关。一个特别详细的模型表明，遗传系统的某些方面是由稳定选择塑造的，而其他方面则是选择中性的。参考实验数据的果蝇，玉米和小鼠的字符，它的结论是，大量的遗传变异可以保持突变的多基因性状，即使有很强的稳定选择。并将该模型的性质与具有连锁位点的杂种优势模型的性质进行了比较。
It is assumed that a character under stabilizing selection is determined genetically by n linked, mutable loci with additive effects and a range of many possible allelic effects at each locus. A general qualitative feature of such systems is that the genetic variance for the character is independent of the linkage map of the loci, provided linkage is not very tight. A particular detailed model shows that certain aspects of the genetic system are moulded by stabilizing selection while others are selectively neutral. With reference to experimental data on characters of Drosophila flies, maize, and mice, it is concluded that large amounts of genetic variation can be maintained by mutation in polygenic characters even when there is strong stabilizing selection. The properties of the model are compared with those of heterotic models with linked loci.