25-Hydroxyvitamin D and Symptomatic Ischemic Stroke: An Original Study and Meta-Analysis
25-Hydroxyvitamin D and Symptomatic Ischemic Stroke: An Original Study and Meta-Analysis
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DOI：
10.1002/ana.23738
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发表时间：
2013-01-01
影响因子：
11.2
通讯作者：
Benn, Marianne
中科院分区：
文献类型：
--
作者：
Brondum-Jacobsen, Peter;Nordestgaard, Borge G.;Benn, Marianne
目的：我们验证了在普通人群中低血浆浓度25-羟基维生素D与症状性缺血性卒中风险增加相关的假设。方法：我们在哥本哈根市心脏研究中测量了10170名普通人群的血浆25-羟基维生素D。在21年的随访中，分别有1256人和164人发生了缺血性和出血性中风。在缺血性卒中的荟萃分析中，我们纳入了10项研究，58,384名参与者和2,644个事件。结果：血浆25-羟基维生素D浓度的逐步降低与缺血性卒中风险的逐步增加相关，这与季节性调整的百分位数类别和25-羟基维生素D临床类别的功能有关（p为趋势）
Objective: We tested the hypothesis that low plasma concentrations of 25-hydroxyvitamin D are associated with increased risk of symptomatic ischemic stroke in the general population.Methods: We measured plasma 25-hydroxyvitamin D in 10,170 individuals from the general population, the Copenhagen City Heart Study. During 21 years of follow-up, 1,256 and 164 persons developed ischemic and hemorrhagic stroke, respectively. In a meta-analysis of ischemic stroke, we included 10 studies, 58,384 participants, and 2,644 events.Results: Stepwise decreasing plasma 25-hydroxyvitamin D concentrations were associated with stepwise increasing risk of ischemic stroke both as a function of seasonally adjusted percentile categories and as a function of clinical categories of 25-hydroxyvitamin D (p for trend